Protein Alignment Cyp4ac1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_608916.1
• Gene: Cyp4ac1 / 33754
• FlyBaseID: FBgn0031693
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 132/530 - (24%)
• Similarity: 240/530 - (45%)
• Gaps: 79/530 - (14%)

  Fly    10 ILLAV-LTLLLKHINKTYFILSLTKRVRTEDGSPLESKVAIMPGKTRFGNNLDILNFTPASVFNF 73
            :|||| |.||..:..:|:   .|.||:.....:||          ...||   :|::. ..::.|
Human    13 LLLAVSLVLLYLYGTRTH---GLFKRLGIPGPTPL----------PLLGN---VLSYR-QGLWKF 60

  Fly    74 VRESTAKAKGQNYLWYFLYAPMYNVVRPE--------EAEEVFQSTKLITKNVVYELIRP--FLG 128
            ..| ..|..|:.:..|....|:..:..|:        |...||.:.:         .:.|  |:.
Human    61 DTE-CYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRR---------SLGPVGFMK 115

  Fly   129 DGLLISTDHKWHSRRKALTPAFHFNVLQSFLGIFKEECKKFLNVLEKNLDAELE------LNQVI 187
            ..:.::.|.:|...|..|:|.|....|:....|..:    :.:||.:||..|.|      |..:.
Human   116 SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQ----YGDVLVRNLRREAEKGKPVTLKDIF 176

  Fly   188 PPFTLNNICETALGVKLDDMSEGNEYRKAIHAIEEVLIQRVCNPL----MYYNWYFFVYGDYRKH 248
            ..::::.|..|:.||.:|.::  |.....:.:.::.|.....:||    :.:.:...|:......
Human   177 GAYSMDVITGTSFGVNIDSLN--NPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS 239

  Fly   249 LQNLRIVHDFSSRIIERKRQQFQQKQLGEVDEFGRKQRYAMLDTLLAAEADGQIDHQGICD---- 309
            |.....::..|..:...|:.:...||...:|..     ..|:|:..:.|.:   .|:.:.|
Human   240 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFL-----QLMIDSQNSKETE---SHKALSDLELA 296

  Fly   310 -EVNTFMFEGYDTTSTCLIFTLLMLALHEDVQKKCYEEVE-----NLPEDSDDISMFQFNKLVYL 368
             :...|:|.||:|||:.|.|||..||.|.|||:|..:|::     ..|...|.:...:     ||
Human   297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME-----YL 356

  Fly   369 ECVIKESLRMFPSVPFIGRQCVEETVVNGMVMPKDTQISIHIYDIMRDPRHFPKPDLFQPDRFLP 433
            :.|:.|:||:||....:.|.|.::..:||:.:||.:.:.|..|.:..||:::.:|:.|:|:||..
Human   357 DMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421

  Fly   434 ENTVNRHPFAYVPFSAGQRNCIGQKFAILEMKVLLAAVIRNFKLLPATQLE-DLTFENGIVLRTQ 497
            :.. :..|:.|.||..|.|||||.:||::.||:.|..|::||...|..:.: .|..:...:|:.:
Human   422 KKD-SIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPE 485

  Fly   498 ENIKVKLSKR 507
            :.|.:|:..|
Human   486 KPIVLKVDSR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4ac1	NP_608916.1	CYP4	83..502	CDD:410721	111/449 (25%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	111/452 (25%)