Protein Alignment tkv and ACVRL1

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_000011.2
• Gene: ACVRL1 / 94
• HGNCID: 175
• Length: 503
• Species: Homo sapiens
• Alignment Length: 494
• Identity: 226/494 - (45%)
• Similarity: 294/494 - (59%)
• Gaps: 45/494 - (9%)

  Fly    81 LTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNG-GFL---MC 141
            :||.|:.   .:....||.   |..|          |..:..||   |..|.|..| |.|   :|
Human    32 VTCTCES---PHCKGPTCR---GAWC----------TVVLVREE---GRHPQEHRGCGNLHRELC 77

  Fly   142 KVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFM 206
            :......:   |..|||.. .||.::  :...:.|.|..:.|.:...|  ..:.|.::..|::..
Human    78 RGRPTEFV---NHYCCDSH-LCNHNV--SLVLEATQPPSEQPGTDGQL--ALILGPVLALLALVA 134

  Fly   207 LIVASLCFTYKRREKLR------KQPRLINSMCNSQLSPLSQLVEQ--SSGSGSGLPLLVQRTIA 263
            |.|..|....:|:||.|      .:..||........|.|..|::.  ::|||||||.|||||:|
Human   135 LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVA 199

  Fly   264 KQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADI 328
            :|:.:|..||||||||||...|..|.||||.|.:.:|.|||||||||.|||:||||||||||:|:
Human   200 RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 264

  Fly   329 KGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHR 393
            ....|.||:.|||.|||.|||:|:|....:.|.....||.|.|.||||||.|||||.||||||||
Human   265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHR 329

  Fly   394 DIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFK 458
            |.||:|:|||.|.||.|||.||||.::...|.:.|..||||||:||||||||.:|:....||.:|
Human   330 DFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYK 394

  Fly   459 RADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPS 523
            ..|:::.||||||:.||  |.|:|    ..|||..|::||||:||:||||..||||....|.||:
Human   395 WTDIWAFGLVLWEIARR--TIVNG----IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPN 453

  Fly   524 RWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            |...|.||:.::::|:|||:|||:.||||||:||||.::
Human   454 RLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	23/91 (25%)
		GS	238..266	CDD:197743	16/29 (55%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)
ACVRL1	NP_000011.2	TFP_LU_ECD_ALK1	29..98	CDD:467064	23/88 (26%)
		Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	174..200	CDD:462503	14/25 (56%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	175/303 (58%)