DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and ACVRL1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_000011.2	Gene:	ACVRL1 / 94	HGNCID:	175	Length:	503	Species:	Homo sapiens

Alignment Length:	494	Identity:	226/494 - (45%)
Similarity:	294/494 - (59%)	Gaps:	45/494 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 LTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNG-GFL---MC 141
            :||.|:.   .:....||.   |..|          |..:..||   |..|.|..| |.|   :|
Human    32 VTCTCES---PHCKGPTCR---GAWC----------TVVLVREE---GRHPQEHRGCGNLHRELC 77

  Fly   142 KVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFM 206
            :......:   |..|||.. .||.::  :...:.|.|..:.|.:...|  ..:.|.::..|::..
Human    78 RGRPTEFV---NHYCCDSH-LCNHNV--SLVLEATQPPSEQPGTDGQL--ALILGPVLALLALVA 134

  Fly   207 LIVASLCFTYKRREKLR------KQPRLINSMCNSQLSPLSQLVEQ--SSGSGSGLPLLVQRTIA 263
            |.|..|....:|:||.|      .:..||........|.|..|::.  ::|||||||.|||||:|
Human   135 LGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVA 199

  Fly   264 KQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADI 328
            :|:.:|..||||||||||...|..|.||||.|.:.:|.|||||||||.|||:||||||||||:|:
Human   200 RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 264

  Fly   329 KGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHR 393
            ....|.||:.|||.|||.|||:|:|....:.|.....||.|.|.||||||.|||||.||||||||
Human   265 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHR 329

  Fly   394 DIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFK 458
            |.||:|:|||.|.||.|||.||||.::...|.:.|..||||||:||||||||.:|:....||.:|
Human   330 DFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYK 394

  Fly   459 RADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPS 523
            ..|:::.||||||:.||  |.|:|    ..|||..|::||||:||:||||..||||....|.||:
Human   395 WTDIWAFGLVLWEIARR--TIVNG----IVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPN 453

  Fly   524 RWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            |...|.||:.::::|:|||:|||:.||||||:||||.::
Human   454 RLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	23/93 (25%)
		GS	238..266	CDD:197743	16/29 (55%)
		S_TKc	267..557	CDD:214567	167/289 (58%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)
ACVRL1	NP_000011.2	Mediates specificity for BMP ligand	73..76		0/2 (0%)
		TGF_beta_GS	173..200	CDD:312125	14/26 (54%)
		STKc_ACVR1_ALK1	196..493	CDD:271044	175/303 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750