Protein Alignment tkv and ACVR1

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001096.1
• Gene: ACVR1 / 90
• HGNCID: 171
• Length: 509
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 238/520 - (45%)
• Similarity: 326/520 - (62%)
• Gaps: 53/520 - (10%)

  Fly    68 DNEKSKTVENARSLTCYCDG-SCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMP 131
            ::||.|.  |.:...|.|:| ||.   :...||   |..|||::.  .::...:|::    ||..
Human    22 EDEKPKV--NPKLYMCVCEGLSCG---NEDHCE---GQQCFSSLS--INDGFHVYQK----GCFQ 72

  Fly   132 PEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFG 196
            ..:.|. :.||....|   |:.:.|| :.|:|||::    |.:|.|.....| .:::.| |.| |
Human    73 VYEQGK-MTCKTPPSP---GQAVECC-QGDWCNRNI----TAQLPTKGKSFP-GTQNFH-LEV-G 125

  Fly   197 SIIISLSVFMLIVASLCFTYKRREKLRKQPRL---------INSMCNSQL--SPLSQLVEQS--S 248
            .||:|:...:.::|.|.....|:.|.|.|.||         |..:..:.:  |.|:.|::.|  |
Human   126 LIILSVVFAVCLLACLLGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLADLLDHSCTS 190

  Fly   249 GSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTV 313
            |||||||.|||||:|:||.::..||||||||||...|:.|.||||.|.:.:|.|||||||:|.||
Human   191 GSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTV 255

  Fly   314 LMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLH 378
            ::||:|||||||:|:....|.||:.|||.|||||||:|||.::.::......:..|:||||||||
Human   256 MLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLH 320

  Fly   379 DEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPE 443
            .|||||.|||||||||:||||||||:||||.|||.||||.::...:.:.:..||||||:||||||
Human   321 IEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPE 385

  Fly   444 VLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDM 508
            ||.:.:....|:.:||.|:::.||||||:.||.      ......|||..|::||||:||:||||
Human   386 VLDETIQVDCFDSYKRVDIWAFGLVLWEVARRM------VSNGIVEDYKPPFYDVVPNDPSFEDM 444

  Fly   509 HAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKT-------LGRLETDC 566
            ..||||...||.||:||..|..|.:::|:|:|||:.||:.||||||:|||       |.:|:|||
Human   445 RKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 509

  Fly   567  566
            Human   510  509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	25/88 (28%)
		GS	238..266	CDD:197743	18/29 (62%)
		STKc_BMPR1	270..562	CDD:271046	165/298 (55%)
ACVR1	NP_001096.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	25/86 (29%)
		TGF_beta_GS	179..206	CDD:462503	16/26 (62%)
		STKc_ACVR1_ALK1	202..499	CDD:271044	169/302 (56%)