DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and XIP1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_199777.1	Gene:	XIP1 / 835028	AraportID:	AT5G49660	Length:	966	Species:	Arabidopsis thaliana

Alignment Length:	590	Identity:	136/590 - (23%)
Similarity:	212/590 - (35%)	Gaps:	182/590 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARS--LTCYCDGSCPD 91
            |:.::.|..:..:|..:....|..:: |:...|...:...|.||..|.:..|  ||    |..|:
plant   467 LSNNQLSGPIPSEVGRLRKLNLLVLQ-GNHLDSSIPDSLSNLKSLNVLDLSSNLLT----GRIPE 526

  Fly    92 NVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPE-DNGGFLMCKVAAVPHLHGKNIV 155
            |:|    |..|....||:              .|..|.:|.. ..||.:
plant   527 NLS----ELLPTSINFSS--------------NRLSGPIPVSLIRGGLV---------------- 557

  Fly   156 CCDKEDFCNRDLYPTYTPKLTTP----APDL--PVSSESLHTLAVFGSI-IISLSVFMLIVASLC 213
                |.|.:       .|.|..|    :.||  |:..|. |......|| .|.:|||:|::..:.
plant   558 ----ESFSD-------NPNLCIPPTAGSSDLKFPMCQEP-HGKKKLSSIWAILVSVFILVLGVIM 610

  Fly   214 F-----TYKRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVG 273
            |     ..|.|..:.:...|.:|..:..:....::            ...||.|.:.:....:||
plant   611 FYLRQRMSKNRAVIEQDETLASSFFSYDVKSFHRI------------SFDQREILESLVDKNIVG 663

  Fly   274 KGRYGEVWLAKWRD-ERVAVKTFFTTEEASWFRE----------TEIYQTVLMRHDNILG----F 323
            .|..|.|:..:.:. |.||||..::........|          ||:.....:||.||:.    |
plant   664 HGGSGTVYRVELKSGEVVAVKKLWSQSNKDSASEDKMHLNKELKTEVETLGSIRHKNIVKLFSYF 728

  Fly   324 IAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQ--KLQLLAFSLASGLAHLHDEIFGTPG 386
            .:.|..        ||:.:|...|:|.|.|....::.:  ....:|..:|.|||:||.::
plant   729 SSLDCS--------LLVYEYMPNGNLWDALHKGFVHLEWRTRHQIAVGVAQGLAYLHHDL----- 780

  Fly   387 KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKY-----NSELDVIHIAQNPRVGTRRYMAPE-VL 445
            .|.|.||||||.|||:..|.|..:||||:|...     :|...|:       .||..|:||| ..
plant   781 SPPIIHRDIKSTNILLDVNYQPKVADFGIAKVLQARGKDSTTTVM-------AGTYGYLAPEYAY 838

  Fly   446 SQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHA 510
            |.:...|       .|:||.|:||.|:       ::|.|               |.|..|.:...
plant   839 SSKATIK-------CDVYSFGVVLMEL-------ITGKK---------------PVDSCFGENKN 874

  Fly   511 VVCVKGFRPPIPSRW------QEDDVLATVSKIMQE---------------CWHPNPTVRLTALR 554
            :|           .|      .::.::.|:.|.:.|               |....||:|.|...
plant   875 IV-----------NWVSTKIDTKEGLIETLDKRLSESSKADMINALRVAIRCTSRTPTIRPTMNE 928

  Fly   555 VKKTL 559
            |.:.|
plant   929 VVQLL 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	17/90 (19%)
		GS	238..266	CDD:197743	3/27 (11%)
		S_TKc	267..557	CDD:214567	84/333 (25%)
		STKc_BMPR1	270..562	CDD:271046	85/334 (25%)
XIP1	NP_199777.1	PLN00113	47..933	CDD:331614	135/588 (23%)
		leucine-rich repeat	73..97	CDD:275380
		leucine-rich repeat	98..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..196	CDD:275380
		leucine-rich repeat	197..220	CDD:275380
		leucine-rich repeat	221..244	CDD:275380
		leucine-rich repeat	245..269	CDD:275380
		leucine-rich repeat	270..293	CDD:275380
		leucine-rich repeat	294..317	CDD:275380
		leucine-rich repeat	318..389	CDD:275380
		leucine-rich repeat	342..366	CDD:275380
		leucine-rich repeat	367..386	CDD:275380
		leucine-rich repeat	390..413	CDD:275380
		leucine-rich repeat	414..437	CDD:275380
		leucine-rich repeat	438..461	CDD:275380
		leucine-rich repeat	462..485	CDD:275380	3/17 (18%)
		leucine-rich repeat	486..509	CDD:275380	4/23 (17%)
		leucine-rich repeat	510..531	CDD:275380	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000