DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and Bmpr1a

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_110476.1	Gene:	Bmpr1a / 81507	RGDID:	70989	Length:	532	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	273/530 - (51%)
Similarity:	339/530 - (63%)	Gaps:	48/530 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LSGMEMGSGPGSEGYEDADNEKSKTVENARSLT---------CYCDGSCPDNVSNGTCETRPGGS 105
            |..|..|:|..|    |.|.:|.   ||..:|.         |||.|.|||:..|.||.|  .|.
  Rat    26 LDSMLHGTGMKS----DVDQKKP---ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCIT--NGH 81

  Fly   106 CFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPT 170
            ||:.::   ::..|  |...|.|||..|  |....||.:....|. :.|.|| :.:.||:.|.||
  Rat    82 CFAIIE---EDDQG--ETTLTSGCMKYE--GSDFQCKDSPKAQLR-RTIECC-RTNLCNQYLQPT 137

  Fly   171 YTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRR-EKLRKQPRLINSMCN 234
            ..|.:..|..|     .|:..|||.  |.:::.:..:||.|.||.||.. :.:..:.|....:..
  Rat   138 LPPVVIGPFFD-----GSVRWLAVL--ISMAVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLEQ 195

  Fly   235 SQL-----SPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAV 292
            .:.     ..|..|::  |||||||||||||||||||||||||.||||||||||:.|||.|:|||
  Rat   196 DEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAV 260

  Fly   293 KTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSV 357
            |.|||||||||||||||||||||||:||||||||||||.|||||:.|||||||.|||:|:|..:.
  Rat   261 KVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCAT 325

  Fly   358 INPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSE 422
            ::.:.|..||:|.|.||.|||.||:||.|||||||||:||||||:|:||.|.|||.|||||:||:
  Rat   326 LDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSD 390

  Fly   423 LDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTT 487
            .:.:.|..|.|||||||||||||.:.|....|:.:..||:||.||::|||.|||.|  .|    .
  Rat   391 TNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCIT--GG----I 449

  Fly   488 CEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA 552
            .|:|.|||:::|||||::|||..|||||..||.:.:||..|:.|..|.|:|.|||..||..||||
  Rat   450 VEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA 514

  Fly   553 LRVKKTLGRL 562
            ||:||||.::
  Rat   515 LRIKKTLAKM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	33/98 (34%)
		GS	238..266	CDD:197743	21/29 (72%)
		S_TKc	267..557	CDD:214567	186/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	187/291 (64%)
Bmpr1a	NP_110476.1	Activin_recp	59..138	CDD:279413	32/89 (36%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		0/1 (0%)
		S_TKc	235..519	CDD:214567	186/289 (64%)
		STKc_BMPR1a	238..524	CDD:271122	187/291 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I762
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1362
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm46139
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970