Protein Alignment tkv and Bmpr1a

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_110476.1
• Gene: Bmpr1a / 81507
• RGDID: 70989
• Length: 532
• Species: Rattus norvegicus
• Alignment Length: 530
• Identity: 273/530 - (51%)
• Similarity: 339/530 - (63%)
• Gaps: 48/530 - (9%)

  Fly    50 LSGMEMGSGPGSEGYEDADNEKSKTVENARSLT---------CYCDGSCPDNVSNGTCETRPGGS 105
            |..|..|:|..|    |.|.:|.   ||..:|.         |||.|.|||:..|.||.|  .|.
  Rat    26 LDSMLHGTGMKS----DVDQKKP---ENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCIT--NGH 81

  Fly   106 CFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPT 170
            ||:.::   ::..|  |...|.|||..|  |....||.:....|. :.|.|| :.:.||:.|.||
  Rat    82 CFAIIE---EDDQG--ETTLTSGCMKYE--GSDFQCKDSPKAQLR-RTIECC-RTNLCNQYLQPT 137

  Fly   171 YTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRR-EKLRKQPRLINSMCN 234
            ..|.:..|..|     .|:..|||.  |.:::.:..:||.|.||.||.. :.:..:.|....:..
  Rat   138 LPPVVIGPFFD-----GSVRWLAVL--ISMAVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLEQ 195

  Fly   235 SQL-----SPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAV 292
            .:.     ..|..|::  |||||||||||||||||||||||||.||||||||||:.|||.|:|||
  Rat   196 DEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAV 260

  Fly   293 KTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSV 357
            |.|||||||||||||||||||||||:||||||||||||.|||||:.|||||||.|||:|:|..:.
  Rat   261 KVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCAT 325

  Fly   358 INPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSE 422
            ::.:.|..||:|.|.||.|||.||:||.|||||||||:||||||:|:||.|.|||.|||||:||:
  Rat   326 LDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSD 390

  Fly   423 LDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTT 487
            .:.:.|..|.|||||||||||||.:.|....|:.:..||:||.||::|||.|||.|  .|    .
  Rat   391 TNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCIT--GG----I 449

  Fly   488 CEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA 552
            .|:|.|||:::|||||::|||..|||||..||.:.:||..|:.|..|.|:|.|||..||..||||
  Rat   450 VEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTA 514

  Fly   553 LRVKKTLGRL 562
            ||:||||.::
  Rat   515 LRIKKTLAKM 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	32/96 (33%)
		GS	238..266	CDD:197743	21/29 (72%)
		STKc_BMPR1	270..562	CDD:271046	187/291 (64%)
Bmpr1a	NP_110476.1	TFP_LU_ECD_BMPR1A	57..140	CDD:467132	33/93 (35%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	107..109		0/1 (0%)
		TGF_beta_GS	205..232	CDD:462503	19/26 (73%)
		STKc_BMPR1a	238..524	CDD:271122	187/291 (64%)