DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and Acvr1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_017447543.1	Gene:	Acvr1 / 79558	RGDID:	620200	Length:	528	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	240/561 - (42%)
Similarity:	333/561 - (59%)	Gaps:	71/561 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ALEALTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDG-S 88
            ::||||... ....||||                     .....:|:.|.  |.:...|.|:| |
  Rat    20 SMEALTLHS-PTQYQPDV---------------------LPSTLDEEPKV--NPKLYMCVCEGLS 60

  Fly    89 CPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKN 153
            |.   :...||   |..|||::.  .::...:|::    ||....:.|. :.||....|   |:.
  Rat    61 CG---NEDHCE---GQQCFSSLS--VNDGFRVYQK----GCFQVYEQGK-MTCKTPPSP---GQA 109

  Fly   154 IVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLA--VFGSIIISLSVFMLIVASLCFTY 216
            :.|| :.|:|||::    |.:|.|.....| .|::.|...  :..|::.::.:|..|:......:
  Rat   110 VECC-QGDWCNRNV----TARLPTKGKSFP-GSQNFHLEVGLIILSVVFAVCLFACILGVALRKF 168

  Fly   217 KRREKLRKQPR-----LINSMCNSQL--SPLSQLVEQS--SGSGSGLPLLVQRTIAKQIQMVRLV 272
            |||.:.|..||     .|..:..:.:  |.|::|::.|  ||||||||.|||||:|:||.::..|
  Rat   169 KRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECV 233

  Fly   273 GKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQM 337
            |||||||||...|:.|.||||.|.:.:|.|||||||:|.||::||:|||||||:|:....|.||:
  Rat   234 GKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQL 298

  Fly   338 LLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILV 402
            .|||.|||||||:|||.::.::......:..|:||||||||.|||||.||.||||||:|||||||
  Rat   299 WLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILV 363

  Fly   403 KRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGL 467
            |:||||.|||.||||.::...:.:.:..||||||:||||||||.:.:....|:.:||.|:::.||
  Rat   364 KKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGL 428

  Fly   468 VLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLA 532
            ||||:.||.      ......|||..|::||||:||:||||..||||...||.||:||..|..|.
  Rat   429 VLWEVARRM------VSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLT 487

  Fly   533 TVSKIMQECWHPNPTVRLTALRVKKT-------LGRLETDC 566
            :::|:|:|||:.||:.||||||:|||       |.:|:|||
  Rat   488 SLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	25/90 (28%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	160/289 (55%)
		STKc_BMPR1	270..562	CDD:271046	164/298 (55%)
Acvr1	XP_017447543.1	Activin_recp	56..121	CDD:395845	23/81 (28%)
		TGF_beta_GS	198..225	CDD:400699	16/26 (62%)
		STKc_ACVR1_ALK1	221..518	CDD:271044	168/302 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338295
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850