DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and tgfbr1b

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001108531.1	Gene:	tgfbr1b / 792928	ZFINID:	ZDB-GENE-091027-1	Length:	505	Species:	Danio rerio

Alignment Length:	508	Identity:	238/508 - (46%)
Similarity:	308/508 - (60%)	Gaps:	58/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 VENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETT---------GMYEEERTYGCM 130
            |:....|.|||. .||    |.||.|  .|.|:.::.:....||         .:...:|.:.|.
Zfish    28 VQQTEGLQCYCH-RCP----NHTCTT--DGLCYVSITRAGSLTTQQSWCIGKGELVPPDRPFVCA 85

  Fly   131 P-PEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRD----LYPTYTPKLTTPAPDL-PVSSESL 189
            | .:|:.|...              :||| .|:||:|    .:|..|.|    .|.| ||:..:|
Zfish    86 PSTKDDSGIYP--------------LCCD-TDWCNKDPDIKAFPVPTQK----PPALGPVAFAAL 131

  Fly   190 HTLAVFGSIIISLSVFMLIVASLCFT---YKRREKLRKQPRLINSMCNSQLSPLSQLVEQ--SSG 249
                :.|.:.: |...|:.|..:|.:   ...|....:.|.|.:...... :.|..|:..  :||
Zfish   132 ----IAGPVCV-LCFLMVTVFYICHSRSVIHHRVPSEEDPSLDHPFITVG-TTLKDLIYDMTTSG 190

  Fly   250 SGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVL 314
            ||||||||||||||:.|.:...:||||:||||..:||.|.||||.|.:.||.|||||.||||||:
Zfish   191 SGSGLPLLVQRTIARTIILQESIGKGRFGEVWRGRWRGEEVAVKIFSSREERSWFREAEIYQTVM 255

  Fly   315 MRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHD 379
            :||:|||||||||.|.||:|||:.|::||||.|||.|||:...:..:.:..|:.|.||||||||.
Zfish   256 LRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLSLSTASGLAHLHM 320

  Fly   380 EIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEV 444
            ||.||.|||||||||:||||||||:||.|.|||.||||:::|..|.|.||.|.||||:|||||||
Zfish   321 EIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEV 385

  Fly   445 LSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMH 509
            |...::.|.||.|||||:|::|||.||:..||  .:.|..    |||.|||||:|.|||:.|:|.
Zfish   386 LDDSINMKHFESFKRADIYAMGLVFWEIASRC--SIGGIH----EDYQLPYHDLVQSDPSVEEMR 444

  Fly   510 AVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            .|||.:..||.||:|||..:.|..::|||:|||:.|...||||||:||||.:|
Zfish   445 RVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	27/103 (26%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	171/289 (59%)
		STKc_BMPR1	270..562	CDD:271046	175/291 (60%)
tgfbr1b	NP_001108531.1	Activin_recp	34..107	CDD:279413	25/94 (27%)
		TGF_beta_GS	178..205	CDD:285687	17/26 (65%)
		TyrKc	207..494	CDD:197581	174/292 (60%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	176/293 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820