DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and bmpr1b

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001072633.1	Gene:	bmpr1b / 780089	XenbaseID:	XB-GENE-483455	Length:	532	Species:	Xenopus tropicalis

Alignment Length:	510	Identity:	274/510 - (53%)
Similarity:	343/510 - (67%)	Gaps:	38/510 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 DADNEKSKTVENA-----RSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEER 125
            :.|:.|..|...|     :.|.|||...||::..|.||.|  .|.||:.|::  || :|:  ...
Frog    40 NVDSRKEDTESTAPAPPQKMLACYCHHHCPEDSFNNTCWT--DGYCFTIVEE--DE-SGL--PVV 97

  Fly   126 TYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLH 190
            |.||:..|  |....|:...:|| ..::|.||..||||||||:||..|   ...||.  ...|:|
Frog    98 TSGCLGLE--GSDFQCRDTPIPH-QRRSIECCTDEDFCNRDLHPTLPP---LKKPDF--VDGSIH 154

  Fly   191 TLAVFGSIIISLSVFMLIVASLC-FTYKRREKLRKQPRLINSMCNSQ--LSP---LSQLVE--QS 247
            .:|:..|:.: .|:.:.|:...| |.|||:|   .:||....:...:  :.|   |..|:|  ||
Frog   155 YMALLISVTV-CSIILAIILIFCYFRYKRQE---ARPRYSIGIEQDETYIPPGESLKDLIEQSQS 215

  Fly   248 SGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQT 312
            ||||||||||||||||||||||:.:|||||||||:.|||.|:||||.||||||||||||||||||
Frog   216 SGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQT 280

  Fly   313 VLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHL 377
            |||||:||||||||||||.|||||:.|||||||.|||:|||..:.::.:.:..||:|..|||.||
Frog   281 VLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDTKAMLKLAYSTVSGLCHL 345

  Fly   378 HDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAP 442
            |.|||||.|||||||||:||||||||:||.|.|||.|||||:.|:.:.:.|..|.||||:|||.|
Frog   346 HTEIFGTKGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPP 410

  Fly   443 EVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFED 507
            |||.:.|:...|:.:..|||||.||:|||:.|||   :||   ...|:|.|||||||||||::||
Frog   411 EVLDESLNRNHFQSYIMADMYSFGLILWEVARRC---ISG---GILEEYQLPYHDVVPSDPSYED 469

  Fly   508 MHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            |..:||::.|||..|:||..|:.|..:.|:|.|||..||..|||||||||||.::
Frog   470 MREIVCIRRFRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	37/89 (42%)
		GS	238..266	CDD:197743	23/32 (72%)
		S_TKc	267..557	CDD:214567	186/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	187/291 (64%)
bmpr1b	NP_001072633.1	Activin_recp	64..136	CDD:395845	31/81 (38%)
		TGF_beta_GS	205..232	CDD:400699	20/26 (77%)
		STKc_BMPR1b	228..532	CDD:271121	197/303 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10729
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20322
Inparanoid	1	1.050	506	1.000	Inparanoid score	I1302
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm49225
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2798
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.090