DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and acvr1b

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001039062.1	Gene:	acvr1b / 733849	XenbaseID:	XB-GENE-483904	Length:	497	Species:	Xenopus tropicalis

Alignment Length:	543	Identity:	243/543 - (44%)
Similarity:	316/543 - (58%)	Gaps:	72/543 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQL 113
            |.|.:..|.|| |..:|               |.|.| .:|..  ||.||.|  .|:|..::..:
Frog    10 AFSLLLFGGGP-SFAFE---------------LKCMC-SNCIQ--SNFTCVT--DGACMVSISNV 53

  Fly   114 YDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVC----------CDKEDFCNR-DL 167
            ..      :|.....|:..||          .||  .||...|          |...|:||: ||
Frog    54 KG------KEYHLRACIGHED----------LVP--PGKPFYCLSSEDIRNTHCCYSDYCNKIDL 100

  Fly   168 -YPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINS 231
             .||....:.||:...||...::..:.||      |...:|||..|...::|....|::..|.:.
Frog   101 GVPTGQIIVDTPSGWGPVELVAVIAIPVF------LICVILIVVVLFHCHQRVYHNRQRLDLEDP 159

  Fly   232 MCNSQLS---PLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVA 291
            .|...|:   .|..||.  .:|||||||||.||||:|:.|.:..::||||:||||..|||...||
Frog   160 SCEMYLAKDKTLPDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGKWRGGDVA 224

  Fly   292 VKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMS 356
            ||.|.:.||.|||||.||||||::||:|||||||||.|.||:|||:.|::||||.|||.|||:..
Frog   225 VKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRY 289

  Fly   357 VINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNS 421
            .:..:.:..|:.|.||||||||.||.||.|||.|||||:||||||||:||.|||||.||||:::|
Frog   290 TVTIEGMIKLSLSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDS 354

  Fly   422 ELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTT 486
            ..|.|.||.|.||||:||||||||.:.::.|.|:.||.||:|::|||.||:.|||  ...|..
Frog   355 ATDTIDIAPNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRC--SAGGFH-- 415

  Fly   487 TCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLT 551
              |:|.||::|:|||||:.|:|..|||.:..||.||:.||..:.|..:.|:|:|||:.|...|||
Frog   416 --EEYQLPFYDLVPSDPSIEEMRKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLT 478

  Fly   552 ALRVKKTLGRLETDCLIDVPIKI 574
            |||:||||.:|.    |...:||
Frog   479 ALRIKKTLSQLS----IQEDVKI 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	27/101 (27%)
		GS	238..266	CDD:197743	17/32 (53%)
		S_TKc	267..557	CDD:214567	166/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)
acvr1b	NP_001039062.1	Activin_recp	26..98	CDD:366445	24/94 (26%)
		TGF_beta_GS	170..197	CDD:369918	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	203..490	CDD:271045	170/292 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010