DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and TGFBR1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001293139.1	Gene:	TGFBR1 / 7046	HGNCID:	11772	Length:	507	Species:	Homo sapiens

Alignment Length:	534	Identity:	243/534 - (45%)
Similarity:	310/534 - (58%)	Gaps:	70/534 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 AMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFS 108
            |.|||||.       ||                 |.:|.|:|.....||.   ||.|  .|.||.
Human    21 AAAAAALL-------PG-----------------ATALQCFCHLCTKDNF---TCVT--DGLCFV 56

  Fly   109 AVQQLYDET---------TGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCN 164
            :|.:..|:.         ..:...:|.:.|.|....|..             ....||: :|.||
Human    57 SVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSV-------------TTTYCCN-QDHCN 107

  Fly   165 RDLYPTYTPKLTTPAPDL-PVSSESLHTLAVFGSIIISLSVFMLIVASLCF---TYKRREKLRKQ 225
            :...||..|.....:|.| ||     ...||....:..:.:.::::..:|.   ....|....:.
Human   108 KIELPTTGPFSVKSSPGLGPV-----ELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEED 167

  Fly   226 PRLINSMCNSQLSPLSQLVEQ--SSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDE 288
            |.|..... |:.:.|..|:..  :||||||||||||||||:.|.:...:||||:||||..|||.|
Human   168 PSLDRPFI-SEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGE 231

  Fly   289 RVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYL 353
            .||||.|.:.||.|||||.||||||::||:|||||||||.|.||:|||:.|::||||.|||.|||
Human   232 EVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYL 296

  Fly   354 SMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVK 418
            :...:..:.:..||.|.||||||||.||.||.|||||||||:||||||||:||.|.|||.||||:
Human   297 NRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVR 361

  Fly   419 YNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGT 483
            ::|..|.|.||.|.||||:||||||||...::.|.||.|||||:|::|||.||:.|||  .:.|.
Human   362 HDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC--SIGGI 424

  Fly   484 KTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTV 548
            .    |||.|||:|:|||||:.|:|..|||.:..||.||:|||..:.|..::|||:|||:.|...
Human   425 H----EDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAA 485

  Fly   549 RLTALRVKKTLGRL 562
            ||||||:||||.:|
Human   486 RLTALRIKKTLSQL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	23/98 (23%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	174/289 (60%)
		STKc_BMPR1	270..562	CDD:271046	178/291 (61%)
TGFBR1	NP_001293139.1	Activin_recp	35..114	CDD:279413	22/97 (23%)
		TGF_beta_GS	180..207	CDD:285687	17/26 (65%)
		Pkinase_Tyr	209..496	CDD:285015	177/292 (61%)
		STKc_TGFbR1_ACVR1b_ACVR1c	213..500	CDD:271045	179/293 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820