DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and acvr1bb

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_687633.5	Gene:	acvr1bb / 559222	ZFINID:	ZDB-GENE-131120-9	Length:	498	Species:	Danio rerio

Alignment Length:	501	Identity:	225/501 - (44%)
Similarity:	298/501 - (59%)	Gaps:	44/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLTCYCDGSCPDNVSNG-TCETRPGGSCFSAVQQLYDETTGMYEEERTYGC------MPPEDNGG 137
            :|.|.|  :.|....:| .|||  .|:|.::...:..      :|:....|      :||  ...
Zfish    22 ALLCNC--TAPHCERDGFKCET--NGACVASTSVIEG------QEQHVRLCIHKEKLVPP--GQP 74

  Fly   138 FLMCKVAAVPHLHGKNIVCCDKEDFCNR-DL-YPTYTPKLTTPAPDLPVSSESLHTLAVFGSIII 200
            |.......:.:.|     || ..|:||. || .|     :.|..|........:...||....:.
Zfish    75 FYCLSAEGLMNTH-----CC-YTDYCNSIDLRLP-----IVTNGPGAGQDWGPVELTAVVAGPVF 128

  Fly   201 SLSVFMLIVASLCFTYKR----REKLRKQPRLINSMCNSQLSPLSQLVE--QSSGSGSGLPLLVQ 259
            .|.|.:|:...|...::|    |::|..:......|..::...|..|:.  .:|||||||||.||
Zfish   129 VLCVLVLLGLFLFQHHQRAYGHRQRLEVEDPSTEHMFLAKDKTLQDLIYDLSTSGSGSGLPLFVQ 193

  Fly   260 RTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFI 324
            ||:|:.|.:..::||||:||||..|||...||||.|.:.||.|||||.|||||:::||:||||||
Zfish   194 RTVARTIVLQEIIGKGRFGEVWRGKWRGGDVAVKIFSSREERSWFREAEIYQTIMLRHENILGFI 258

  Fly   325 AADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPA 389
            |||.|.||:|||:.|::||||.|||.|||:...:..:.:..||.|.||||||||.||.||.|||.
Zfish   259 AADNKDNGTWTQLWLVSDYHENGSLFDYLNRYSVTIEGMIKLALSAASGLAHLHMEILGTQGKPG 323

  Fly   390 IAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQF 454
            |||||:||||||||:|..|||||.||||::.|..|.|.||.|.||||:||||||||.:.::.:.|
Zfish   324 IAHRDLKSKNILVKKNCTCAIADLGLAVRHESITDTIDIAPNQRVGTKRYMAPEVLEESINMRHF 388

  Fly   455 EEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRP 519
            :.||.||:|::|||.||:.|||  ...|..    |:|.|||:|:|||||:.|:|..|||.:..||
Zfish   389 DSFKCADIYALGLVYWEIARRC--NAGGIH----EEYQLPYYDLVPSDPSIEEMRKVVCDQRLRP 447

  Fly   520 PIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRLETD 565
            .||:.||..:.|..:.|||:|||:.|...||||||:||||.:|..|
Zfish   448 NIPNWWQSYEALRVMGKIMRECWYANGAARLTALRIKKTLSQLSVD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	24/98 (24%)
		GS	238..266	CDD:197743	16/29 (55%)
		S_TKc	267..557	CDD:214567	166/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)
acvr1bb	XP_687633.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750