Protein Alignment tkv and acvr2aa

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_021334336.1
• Gene: acvr2aa / 553359
• ZFINID: ZDB-GENE-980526-227
• Length: 538
• Species: Danio rerio
• Alignment Length: 537
• Identity: 181/537 - (33%)
• Similarity: 259/537 - (48%)
• Gaps: 87/537 - (16%)

  Fly    63 GYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTY 127
            |.|....:|.|      .|.|:....   ||| ||.|....| |:......||.|.
Zfish    47 GIEPCVGDKDK------RLHCFATWR---NVS-GTVEIVKQG-CWLDDVNCYDSTE--------- 91

  Fly   128 GCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTP----AP------DL 182
             |:..:::.....|              ||: .:.||...:  |.|. |.|    ||      |.
Zfish    92 -CVEKKEDPDVFFC--------------CCE-GNMCNEKFF--YNPN-TAPVQSKAPFSDTKSDT 137

  Fly   183 PVSSESLHTLA----VFGSIIISLSVFMLIVA--SLCFTYKRREKLRKQPRLINSMCNSQLSPLS 241
            .|...:.:.|.    :|.:::.|:...|.|.|  .|.|...|..||...|.|:.:      ....
Zfish   138 KVFKATSNPLTQKPPLFSTLLYSIVPIMGIAAIVLLSFWMYRHHKLAYPPVLVPT------QHAF 196

  Fly   242 QLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRE 306
            .::.:..|.....|.|||    |.:|::.:..:||:|.||.|:..::.||||.|...::.||..|
Zfish   197 HIMIEDPGPMPPSPTLVQ----KPLQLLEIKARGRFGCVWKAQLLNDYVAVKIFPIQDKLSWQNE 257

  Fly   307 TEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLA 371
            .:||....|||:|||.||.|:.:|:....::.|||.|||..||.|||..:|:...:|..:|.::|
Zfish   258 YDIYNIPGMRHENILQFIGAEKRGSNLDIELWLITAYHEKSSLTDYLKANVVTWNELCHIAQTMA 322

  Fly   372 SGLAHLHDEIFGTPG-----KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKY---NSELDVIHI 428
            .|||:||.:.   ||     ||||||||.||||:|:|.|....|||||||:|:   .|..|.
Zfish   323 RGLAYLHSDF---PGHRDGHKPAIAHRDFKSKNVLLKTNLTACIADFGLALKFEAGKSAGDT--- 381

  Fly   429 AQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYAL 493
              :.:||||||||||||...:: .|.:.|.|.|||:|||||||:..|| |...|    ..::|.|
Zfish   382 --HGQVGTRRYMAPEVLEGAIN-FQRDAFLRIDMYAVGLVLWELAARC-TASDG----PVDEYML 438

  Fly   494 PYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKT 558
            |:.:.|...||.|||..||..|..||.:...||:...||.:.:.::|||......||:|..|::.
Zfish   439 PFEEEVGQHPTLEDMQEVVVHKKLRPTLRECWQKHPGLAMLCETIEECWDHEAEARLSAGCVEER 503

  Fly   559 LGRLETDCLIDVPIKIV 575
            :.:::....:..|.:||
Zfish   504 VVQMQRQTSVSAPEEIV 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	19/87 (22%)
		GS	238..266	CDD:197743	6/27 (22%)
		STKc_BMPR1	270..562	CDD:271046	127/299 (42%)
acvr2aa	XP_021334336.1	TFP_LU_ECD_ACVR2A	25..120	CDD:467151	24/110 (22%)
		STKc_ACVR2a	221..510	CDD:271043	127/302 (42%)