Protein Alignment tkv and acvr1

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_001017357.1
• Gene: acvr1 / 550111
• XenbaseID: XB-GENE-478850
• Length: 512
• Species: Xenopus tropicalis
• Alignment Length: 536
• Identity: 229/536 - (42%)
• Similarity: 323/536 - (60%)
• Gaps: 66/536 - (12%)

  Fly    57 SGPGSEGYEDADNEKSKTVENARSLTCYCDG-SCPDNVSNGTCETRPGGSCFSAVQQLYDETTGM 120
            |.|..|      :|:.|.  ||....|.|:| ||      |:.:...|..||:::    ....|:
 Frog    17 SSPSME------DEEMKL--NAGQYKCVCEGMSC------GSGDHCYGQQCFASL----SNNDGV 63

  Fly   121 YEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLT-----TPAP 180
            ...::  ||....:.|. :.||   .|....:.:.|| :.|.||.::    |.|:|     |...
 Frog    64 LVSQK--GCFQVYEQGK-MTCK---TPPSQDQAVECC-QSDLCNMNI----TVKITDLTGRTKQG 117

  Fly   181 DLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRL---------INSMCNSQ 236
            :.|  :.|:.||.:|   |::..:.:::::.|.....|:.:.|....|         |:.:..|.
 Frog   118 EAP--NYSVETLTIF---ILAPVIVLVVLSVLAVLIFRKIQQRHMQMLSNRDAEYGTIDGLIASN 177

  Fly   237 L--SPLSQLVEQS--SGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFT 297
            :  |.|:::::.|  ||||||||.|||||:|:||.:...||||||||||...|:.|.||||.|.:
 Frog   178 VGDSTLAEMLDHSCTSGSGSGLPFLVQRTVARQITLAECVGKGRYGEVWRGLWQGESVAVKIFSS 242

  Fly   298 TEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQK 362
            .:|.|||||||:|.|||:||:|||||||:|:....|.||:.|||.|||:|||:|||.::.::...
 Frog   243 RDEKSWFRETELYNTVLLRHENILGFIASDMTSRNSSTQLWLITHYHELGSLYDYLQVTTLDSVT 307

  Fly   363 LQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIH 427
            ...:..|:||||||||.|||||.|||||:|||:||||:|||:||||.|||.||||.::...:.:.
 Frog   308 CLRIVLSIASGLAHLHVEIFGTQGKPAISHRDLKSKNVLVKKNGQCCIADLGLAVMHSQTTNQLD 372

  Fly   428 IAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYA 492
            :..||||||:||||||||.:.:....|:.:||.|:|:.||||||:.||.      ......|:|.
 Frog   373 VGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIYAFGLVLWEVARRM------VSNGIVEEYK 431

  Fly   493 LPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKK 557
            .|::||||:||:||||..||||...||.||:||..|..|..::|:|:|||:.||:.||||||:||
 Frog   432 PPFYDVVPNDPSFEDMKKVVCVDQQRPNIPNRWFSDPTLTALAKLMKECWYQNPSARLTALRIKK 496

  Fly   558 T-------LGRLETDC 566
            |       |.:|::||
 Frog   497 TLTKIDNSLDKLKSDC 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	21/88 (24%)
		GS	238..266	CDD:197743	17/29 (59%)
		STKc_BMPR1	270..562	CDD:271046	163/298 (55%)
acvr1	NP_001017357.1	TFP_LU_ECD_ALK2	33..103	CDD:467065	21/86 (24%)
		TGF_beta_GS	182..209	CDD:462503	15/26 (58%)
		STKc_ACVR1_ALK1	205..502	CDD:271044	167/302 (55%)