DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and babo

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_476999.1	Gene:	babo / 35900	FlyBaseID:	FBgn0011300	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	597	Identity:	246/597 - (41%)
Similarity:	346/597 - (57%)	Gaps:	76/597 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LQATSGTADGLFE--EIALEALTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDA----- 67
            |:|.:|||...::  ..:|.|..||..:.|         |:|:|.:....|..|.....|
  Fly    56 LRAPAGTAGHAYQSPSSSLAADNRSHDNNN---------ASAVSMLLPQDGDASGAVAPAVTPQL 111

  Fly    68 ----DNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYG 128
                ....:|..||  .:.|:|| :|.:  ||..|||  .|.||::|::..|.:...     :|.
  Fly   112 PIYIAQPSAKKPEN--KIKCHCD-TCKE--SNNICET--DGFCFTSVEKNSDGSIIF-----SYR 164

  Fly   129 CM------PPEDNGGFLMCKVAAVPHLH--------GKN--IVCCDKEDFCNRDLYPTYTPKLTT 177
            |:      ||   |..:.|.    ..||        |:|  ..||...|||||.|:|....:.:.
  Fly   165 CLHKSQIFPP---GRSIWCN----DGLHGGPTARPVGRNGAHACCKDRDFCNRFLWPKTKDQRSD 222

  Fly   178 PAPD---LPVSSESLHTLA--VFGSIIISLSVFMLIVASLCFTYKRREK-------LRKQPRLIN 230
            ...:   :.|.....|.|.  .|.:||:..::|:....:..:.|.:|.|       ..|:....:
  Fly   223 RVEEGRQISVQDYVPHRLTSWEFVAIILGATLFICFTGTSTWYYCQRRKRMASGRTFAKEDSAYD 287

  Fly   231 SMCNSQLSPLSQLVEQ-SSGSGS-GLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVK 293
            .:.|.. :.:..::|. :||||| ||||||||:||:|:|:..::||||:||||..:||.|.||||
  Fly   288 PILNGN-TTIHDIIEMTTSGSGSAGLPLLVQRSIARQVQLCHVIGKGRFGEVWRGRWRGENVAVK 351

  Fly   294 TFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVI 358
            .|.:.||.|||||.||||||::||:|||||||||.|.||:|||:.|:|||||.|||.|||:...:
  Fly   352 IFSSREECSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVTDYHENGSLFDYLTTHPV 416

  Fly   359 NPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSEL 423
            :...:..::.|:|:||||||.:|.||.|||||||||:||||||||.|..|||.|.||||::..:.
  Fly   417 DTNTMLNMSLSIATGLAHLHMDIVGTRGKPAIAHRDLKSKNILVKSNLSCAIGDLGLAVRHVEKN 481

  Fly   424 DVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTC 488
            |.:.|....||||:||||||||.:.::.:.|:.:||||:|:.||:|||:.|||      ......
  Fly   482 DSVDIPSTHRVGTKRYMAPEVLDESMNDQHFDSYKRADVYAFGLILWEIARRC------NMGMIY 540

  Fly   489 EDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTAL 553
            ::|.|||:|||..||:.|:|..|||::..||.||:||...|||..::|:|:|||:|||..|||||
  Fly   541 DEYQLPYYDVVQPDPSIEEMKKVVCIEKCRPNIPNRWHASDVLHNMAKVMKECWYPNPVARLTAL 605

  Fly   554 RVKKTLGRLETD 565
            |:||||..:..:
  Fly   606 RIKKTLASISVE 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	33/105 (31%)
		GS	238..266	CDD:197743	16/29 (55%)
		S_TKc	267..557	CDD:214567	161/289 (56%)
		STKc_BMPR1	270..562	CDD:271046	164/291 (56%)
babo	NP_476999.1	Activin_recp	127..214	CDD:279413	32/103 (31%)
		GS	294..324	CDD:197743	16/29 (55%)
		Pkinase_Tyr	324..611	CDD:285015	163/292 (56%)
		STKc_TGFbR1_ACVR1b_ACVR1c	328..615	CDD:271045	164/292 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm14704
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
	9	8.900