DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and sax

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001246193.1	Gene:	sax / 35731	FlyBaseID:	FBgn0003317	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	232/578 - (40%)
Similarity:	332/578 - (57%)	Gaps:	77/578 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RSEFSANVQPDV-------EAMAAAALSGMEMGSGP-GSEGYEDADNEKSKTVENARSLTCY-CD 86
            |:|.|.:::.|:       .:.::|.|:|.|:.:.| .|.......:.|||. ...|...|| |:
  Fly    20 RAEISDHLREDIPDLDMELSSASSAHLNGKELPAVPQNSVQTHPRRHIKSKR-RMKRRYKCYSCE 83

  Fly    87 GSCPDNVS-NGTCETRPGGSCFSAVQQLYDET---TGMYEEERTYGCMPPEDNGGFLMCKVAAVP 147
            ..|.|... ..||:        :|:|.....|   .|..:|.|  ||....|... ::|...::
  Fly    84 PPCRDPYEFTHTCQ--------NAIQCWKSRTRDADGQVQESR--GCSTSPDQLP-MICSQNSL- 136

  Fly   148 HLHGK---------NIVCCDKEDFCNRDLYPTYTP----KLTTPAPDLPVSSESLHTLAVFGSII 199
            .::|.         |:||| ..|:||...:|...|    .:|....|  .||.|...:||.|..:
  Fly   137 KINGPSKRNTGKFVNVVCC-AGDYCNEGDFPELLPFDSNDVTVITAD--TSSISKMLVAVLGPFL 198

  Fly   200 ISLSVFMLIVASLCFTYKR--REKL-----RKQPRLINSMCNSQL--------SPLSQLVEQS-- 247
                |..|:.|...|..:|  |::|     ::.|...  :.|.:|        |.|.:.::.|
  Fly   199 ----VIALLGAVTIFFIRRSHRKRLAASRTKQDPEAY--LVNDELLRATSAGDSTLREYLQHSVT 257

  Fly   248 SGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQT 312
            ||||||||||||||:|||:.::..:|:|:|||||...|..|.:|||.||:.:|.||.||||||.|
  Fly   258 SGSGSGLPLLVQRTLAKQVTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYST 322

  Fly   313 VLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHL 377
            :|:||:||||||.:|:....|.||:.|:|.|:.:|||.|:|:.:.::...:..:..|:|:||.||
  Fly   323 ILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHL 387

  Fly   378 HDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAP 442
            |.||||..||||:||||:|||||||..||.|.||||||||.::.....:.:..||:|||:|||||
  Fly   388 HTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAP 452

  Fly   443 EVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTC---EDYALPYHDVVPSDPT 504
            |||.:.:|.:.||..:|.|:|:.||||||:.||         |.:|   |:|.:|::||||.||:
  Fly   453 EVLDESIDLECFEALRRTDIYAFGLVLWEVCRR---------TISCGIAEEYKVPFYDVVPMDPS 508

  Fly   505 FEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            ||||..|||:..:||.||:||..|.::..:||:|:||||.||.|||.|||:|||:.:|
  Fly   509 FEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTIHKL 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	26/103 (25%)
		GS	238..266	CDD:197743	19/29 (66%)
		S_TKc	267..557	CDD:214567	149/292 (51%)
		STKc_BMPR1	270..562	CDD:271046	152/294 (52%)
sax	NP_001246193.1	Activin_recp	77..168	CDD:279413	26/103 (25%)
		TM_EGFR-like	182..218	CDD:213052	13/41 (32%)
		TGF_beta_GS	247..274	CDD:285687	16/26 (62%)
		STKc_ACVR1_ALK1	270..567	CDD:271044	158/306 (52%)
		TyrKc	276..553	CDD:197581	143/285 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445032
Domainoid	1	1.000	207	1.000	Domainoid score	I1682
eggNOG	1	0.900	-	-		E2759_KOG2052
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I1547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	1	1.000	-	-		otm14704
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
	10	9.900