DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and bmpr1ba

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_571532.1	Gene:	bmpr1ba / 30742	ZFINID:	ZDB-GENE-991208-8	Length:	530	Species:	Danio rerio

Alignment Length:	518	Identity:	268/518 - (51%)
Similarity:	329/518 - (63%)	Gaps:	63/518 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 EKSKTVENA-----RSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEER---- 125
            |:.:|..:|     |.|.|||...||::.:|.||.|  .|.||:           |.|||.
Zfish    43 ERRETGSDAPALPQRFLWCYCYHHCPEDSTNNTCRT--DGYCFT-----------MVEEEGGAAV 94

  Fly   126 -TYGCMPPEDNGGFLMCKVAAVPHLHGKN---IVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSS 186
             |.||:...  |....|:...    :.|.   :.||..:|:|||||:|| .|.|.||:    ...
Zfish    95 VTSGCLGLV--GSEFQCRDTG----NSKQRRALECCTDQDYCNRDLHPT-LPPLRTPS----YVV 148

  Fly   187 ESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINSMCNSQLSP----------LS 241
            ..:|.:|:..|:.:...:...|:....|.|||.|   ..||.     :..|.|          |.
Zfish   149 GDIHHIALLISVSVCSFILTFIIIFCYFRYKRHE---LAPRY-----SLGLHPDESFIPAGESLR 205

  Fly   242 QLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWF 304
            .|:|  ||||||||||||||||||||||||..:|||||||||:.:||.|:||||.||||||||||
Zfish   206 DLIEQSQSSGSGSGLPLLVQRTIAKQIQMVTQIGKGRYGEVWMGRWRGEKVAVKVFFTTEEASWF 270

  Fly   305 RETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFS 369
            ||||||||||||||||||||||||||.|||||:.|||||||.|||:|||..:.::.:.:..||:|
Zfish   271 RETEIYQTVLMRHDNILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKCTTLDSRAMLKLAYS 335

  Fly   370 LASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRV 434
            ..|||.|||.|||||.|||||||||:|||||||||||.|.|||.|||||:.|:.:.:.|..|.||
Zfish   336 SVSGLCHLHTEIFGTQGKPAIAHRDLKSKNILVKRNGACCIADLGLAVKFISDTNEVDIPLNTRV 400

  Fly   435 GTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVV 499
            ||:|:||||||.:.|:...|:.:..|||||.||:|||::|||.|  .|    ..|:|.|||||.|
Zfish   401 GTKRFMAPEVLDETLNRNHFQSYIMADMYSFGLILWEISRRCVT--GG----IVEEYQLPYHDHV 459

  Fly   500 PSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            |:||::|||..|||:|..||..|:||..|:.|..:.|:|.|||..||..|||||||||||.::
Zfish   460 PNDPSYEDMREVVCIKRIRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKM 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	32/97 (33%)
		GS	238..266	CDD:197743	23/39 (59%)
		S_TKc	267..557	CDD:214567	186/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	187/291 (64%)
bmpr1ba	NP_571532.1	Activin_recp	61..138	CDD:279413	32/96 (33%)
		STKc_BMPR1b	226..530	CDD:271121	197/303 (65%)
		S_TKc	233..517	CDD:214567	186/289 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577729
Domainoid	1	1.000	59	1.000	Domainoid score	I10628
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20322
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900