DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and acvr1l

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_571420.1	Gene:	acvr1l / 30615	ZFINID:	ZDB-GENE-990415-9	Length:	506	Species:	Danio rerio

Alignment Length:	508	Identity:	218/508 - (42%)
Similarity:	310/508 - (61%)	Gaps:	47/508 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVA 144
            |:.|.|.||   :.:...|   .|..|:::|....|.||  ::.    ||:....:........|
Zfish    25 SIDCMCVGS---DCNEQQC---TGDQCYTSVIISNDVTT--FKR----GCLIGPASKRMTCSATA 77

  Fly   145 AVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLH------TLAVFGS-IIISL 202
            :..|:    :.|| .:..||.::......:|...:|:   ..:::|      .|.|.|. :::.|
Zfish    78 SASHV----VECC-SQHMCNANVSKETLLRLLLTSPE---EKKTVHYRVEMLVLFVLGPFVVLGL 134

  Fly   203 SVFMLIVASLCFTYKRREKLRK---QPRLINSMCNSQL--SPLSQLVEQS--SGSGSGLPLLVQR 260
            ..|:.::......:.|.|:|.:   :...|:.:..|.:  |.|:.|::.|  ||||||||.||||
Zfish   135 LSFLALLVCRRLHHGRLERLHEFDTEQGAIDGLIASNVGDSTLADLMDHSCTSGSGSGLPFLVQR 199

  Fly   261 TIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIA 325
            |:|:||.:|..||||||||||..:|:.|.||||.|.:.:|.|||||||||.|||:||:|||||:|
Zfish   200 TVARQISLVECVGKGRYGEVWRGQWQGENVAVKIFSSRDEKSWFRETEIYNTVLLRHENILGFMA 264

  Fly   326 ADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAI 390
            :|:....|.||:.|||.|||.|||:|||....:.......:|.|:||||.|||.|||||.|||||
Zfish   265 SDMTSRNSSTQLWLITHYHENGSLYDYLQRVAVEMADGLHMAASIASGLVHLHTEIFGTEGKPAI 329

  Fly   391 AHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFE 455
            ||||:||||||||::.||.|||.||||.:....:.:.:..||:|||:||||||||.:.:....|:
Zfish   330 AHRDLKSKNILVKKDLQCCIADLGLAVTHTQSDNQLDVGNNPKVGTKRYMAPEVLDETIQTDCFD 394

  Fly   456 EFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPP 520
            .:||.|:::.||||||:.||  |..:|    ..|:|..|::|:||:||:|:||..||||:..||.
Zfish   395 AYKRVDIWAFGLVLWEIARR--TISNG----IVEEYKPPFYDLVPNDPSFDDMRKVVCVEQQRPF 453

  Fly   521 IPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL-------ETDC 566
            ||:||..|..|:.:.|:|:|||:.||:.||||||:||||.::       :|||
Zfish   454 IPNRWFSDPTLSALVKLMKECWYQNPSARLTALRIKKTLDKIHSSLEKGKTDC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	19/89 (21%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	158/289 (55%)
		STKc_BMPR1	270..562	CDD:271046	161/291 (55%)
acvr1l	NP_571420.1	Activin_recp	28..94	CDD:307282	19/82 (23%)
		TGF_beta_GS	176..203	CDD:312125	16/26 (62%)
		STKc_ACVR1_ALK1	199..496	CDD:271044	167/302 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850