DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and Tgfbr1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_006238092.2	Gene:	Tgfbr1 / 29591	RGDID:	3852	Length:	501	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	237/500 - (47%)
Similarity:	306/500 - (61%)	Gaps:	48/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDET---------TGMYEEERTYGCMPPE 133
            |::|.|:|.....||.   ||||  .|.||.:|.:..|:.         ..:...:|.:.|.|..
  Rat    27 AKALQCFCHLCTKDNF---TCET--DGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS 86

  Fly   134 DNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDL-PVSSESLHTLAVFGS 197
                    |..||.:       ||: :|.||:...||..|.....:..| ||     ...||...
  Rat    87 --------KTGAVTY-------CCN-QDHCNKIELPTTGPFSEKQSAGLGPV-----ELAAVIAG 130

  Fly   198 IIISLSVFMLIVASLCF---TYKRREKLRKQPRLINSMCNSQLSPLSQLVEQ--SSGSGSGLPLL 257
            .:..:.:.::::..:|.   ....|....:.|.|..... |:.:.|..|:..  :||||||||||
  Rat   131 PVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFI-SEGTTLKDLIYDMTTSGSGSGLPLL 194

  Fly   258 VQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILG 322
            ||||||:.|.:...:||||:||||..|||.|.||||.|.:.||.|||||.||||||::||:||||
  Rat   195 VQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILG 259

  Fly   323 FIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGK 387
            |||||.|.||:|||:.|::||||.|||.|||:...:..:.:..||.|.||||||||.||.||.||
  Rat   260 FIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGK 324

  Fly   388 PAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPK 452
            |||||||:||||||||:||.|.|||.||||:::|..|.|.||.|.||||:||||||||...::.|
  Rat   325 PAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMK 389

  Fly   453 QFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGF 517
            .||.|||||:|::|||.||:.|||  .:.|..    |||.|||:|:|||||:.|:|..|||.:..
  Rat   390 HFESFKRADIYAMGLVFWEIARRC--SIGGIH----EDYQLPYYDLVPSDPSVEEMRKVVCEQKL 448

  Fly   518 RPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            ||.||:|||..:.|..::|||:|||:.|...||||||:||||.:|
  Rat   449 RPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	26/98 (27%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	174/289 (60%)
		STKc_BMPR1	270..562	CDD:271046	178/291 (61%)
Tgfbr1	XP_006238092.2	Activin_recp	30..108	CDD:279413	26/98 (27%)
		TGF_beta_GS	174..201	CDD:285687	17/26 (65%)
		Pkinase_Tyr	203..490	CDD:285015	177/292 (61%)
		STKc_TGFbR1_ACVR1b_ACVR1c	207..494	CDD:271045	178/292 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920