Protein Alignment tkv and Acvr2a

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_063139269.1
• Gene: Acvr2a / 29263
• RGDID: 70911
• Length: 521
• Species: Rattus norvegicus
• Alignment Length: 541
• Identity: 173/541 - (31%)
• Similarity: 261/541 - (48%)
• Gaps: 99/541 - (18%)

  Fly    29 LTRSE------FSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDG 87
            |.|||      |:||.:.|     ....:|:|       ..|.|.|..:.          |:...
  Rat    22 LGRSETQECLFFNANWERD-----RTNQTGVE-------PCYGDKDKRRH----------CFATW 64

  Fly    88 SCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGK 152
            .   |:| |:.|....| |:......||.|          .|:..:|:           |.::
  Rat    65 K---NIS-GSIEIVKQG-CWLDDINCYDRT----------DCIEKKDS-----------PEVY-- 101

  Fly   153 NIVCCDKEDFCNRDLYPTYTPKLTTPAP-DLPVSSESLHTLAVFGSIIISLSVFMLI--VASLCF 214
              .||.:.:.||...  :|.|::....| ..||:.:..:    :..::.||...|||  :....|
  Rat   102 --FCCCEGNMCNEKF--SYFPEMEVTQPTSNPVTPKPPY----YNILLYSLVPLMLIAGIVICAF 158

  Fly   215 TYKRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGE 279
            ...|..|:...|.|:.:      .....::.:..|.....|||.    .|.:|::.:..:||:|.
  Rat   159 WVYRHHKMAYPPVLVPT------QHAFHIMIEDPGPPPPSPLLG----LKPLQLLEVKARGRFGC 213

  Fly   280 VWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYH 344
            ||.|:..:|.||||.|...::.||..|.|:|....|:|:|||.||.|:.:|......:.|||.:|
  Rat   214 VWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFH 278

  Fly   345 EMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPG-----KPAIAHRDIKSKNILVKR 404
            |.|||.|:|..:|::..:|..:|.::|.|||:||::|   ||     ||||:||||||||:|:|.
  Rat   279 EKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDI---PGLKDGHKPAISHRDIKSKNVLLKN 340

  Fly   405 NGQCAIADFGLAVKY---NSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVG 466
            |....|||||||:|:   .|..|.     :.:||||||||||||...:: .|.:.|.|.|||::|
  Rat   341 NLTACIADFGLALKFEAGKSAGDT-----HGQVGTRRYMAPEVLEGAIN-FQRDAFLRIDMYAMG 399

  Fly   467 LVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVL 531
            |||||:..|| |...|    ..::|.||:.:.:...|:.|||..||..|..||.:...||:...:
  Rat   400 LVLWELASRC-TAADG----PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGM 459

  Fly   532 ATVSKIMQECWHPNPTVRLTA 552
            |.:.:.::|||..:...||:|
  Rat   460 AMLCETIEECWDHDAEARLSA 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	17/87 (20%)
		GS	238..266	CDD:197743	5/27 (19%)
		STKc_BMPR1	270..562	CDD:271046	122/291 (42%)
Acvr2a	XP_063139269.1	None