DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and Acvr1c

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_620790.2	Gene:	Acvr1c / 245921	RGDID:	621789	Length:	493	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	238/511 - (46%)
Similarity:	319/511 - (62%)	Gaps:	64/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 ARSLTC---YCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGFL 139
            |..|.|   .||.      ||.||:|.  |:|:::|..    |.|  :|:....|:...:....:
  Rat    23 AAGLKCVCLLCDS------SNFTCQTE--GACWASVML----TNG--KEQVIKSCVSLPELNAQV 73

  Fly   140 MCKVAAVPHLHGKNIV----CCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIII 200
            .|        |..|.|    || ..||||     ..|..|.|.:||.|....:..|      ::|
  Rat    74 FC--------HSSNNVTKTECC-FTDFCN-----NITLHLPTASPDAPRLGPTELT------VVI 118

  Fly   201 SLSVFMLIVASL----------CFTYKRREKLR-KQPRLINSMCNSQLSPLSQLV--EQSSGSGS 252
            ::.|.:|.:|::          | ||::.::.. ::|....|:.|:. ..|..|:  ..:|||||
  Rat   119 TVPVCLLSIAAMLTIWACQDRQC-TYRKTKRHNVEEPLAEYSLVNAG-KTLKDLIYDATASGSGS 181

  Fly   253 GLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRH 317
            |||||||||||:.|.:..:|||||:||||..:|..|.||||.|.:.:|.|||||.||||||::||
  Rat   182 GLPLLVQRTIARTIVLQEIVGKGRFGEVWHGRWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRH 246

  Fly   318 DNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIF 382
            :|||||||||.|.||:|||:.|:::|||.|||:|||:.:::....:..||.|:||||||||.||.
  Rat   247 ENILGFIAADNKDNGTWTQLWLVSEYHEQGSLYDYLNRNIVTVAGMVKLALSIASGLAHLHMEIV 311

  Fly   383 GTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQ 447
            ||.||||||||||||||||||:...|||||.|||||::|.::.|.|.|||:|||:||||||:|..
  Rat   312 GTQGKPAIAHRDIKSKNILVKKCDTCAIADLGLAVKHDSIMNTIDIPQNPKVGTKRYMAPEMLDD 376

  Fly   448 QLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVV 512
            .::...||.|||||:||||||.||:.|||  .|.|    ..|:|.|||:|:|||||:.|:|..||
  Rat   377 TMNVNIFESFKRADIYSVGLVYWEIARRC--SVGG----LVEEYQLPYYDMVPSDPSIEEMRKVV 435

  Fly   513 CVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL--ETDC 566
            |.:..||.:|::||..:.|..:.:||:|||:.|...||||||||||:.:|  :.||
  Rat   436 CDQKLRPNLPNQWQSCEALRVMGRIMRECWYANGAARLTALRVKKTISQLCVKEDC 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	26/96 (27%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	169/289 (58%)
		STKc_BMPR1	270..562	CDD:271046	172/291 (59%)
Acvr1c	NP_620790.2	Activin_recp	33..95	CDD:395845	24/89 (27%)
		TGF_beta_GS	166..193	CDD:400699	17/26 (65%)
		STKc_TGFbR1_ACVR1b_ACVR1c	199..486	CDD:271045	172/292 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750