Protein Alignment tkv and Tgfbr2

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_033397.3
• Gene: Tgfbr2 / 21813
• MGIID: 98729
• Length: 592
• Species: Mus musculus
• Alignment Length: 538
• Identity: 173/538 - (32%)
• Similarity: 254/538 - (47%)
• Gaps: 101/538 - (18%)

  Fly    77 NARSLTCYCDGSCPDNVS-NGTCETRPGGSCFSAVQQLYDET----TGMYEEERTYGCMPPEDNG 136
            :.|..||....||..|.| ...|| :|...|. ||.:..|:.    |..::.:.||.....||..
Mouse    80 DVRLSTCDNQKSCMSNCSITAICE-KPHEVCV-AVWRKNDKNITLETVCHDPKLTYHGFTLEDAA 142

  Fly   137 G--------------FLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDLPVSSE 187
            .              |.||              .|:.|: ||.  |..::.:.||.:|||.:...
Mouse   143 SPKCVMKEKKRAGETFFMC--------------ACNMEE-CND--YIIFSEEYTTSSPDLLLVII 190

  Fly   188 SLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKL-----RKQPRL------------------I 229
            .:..:::...:.|:::|   |:...|:...|::||     ..:||.                  |
Mouse   191 QVTGVSLLPPLGIAIAV---IIIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDI 252

  Fly   230 NSMCNSQLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRD------E 288
            :|.|.:.::..::|          ||          |::..||||||:.||:.||.:.      |
Mouse   253 SSTCANNINHNTEL----------LP----------IELDTLVGKGRFAEVYKAKLKQNTSEQFE 297

  Fly   289 RVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYL 353
            .||||.|...|.:||..|.:|:..:.::|:|||.|:.|:.:......|..|||.:|..|:|.:||
Mouse   298 TVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL 362

  Fly   354 SMSVINPQKLQLLAFSLASGLAHLHDEIFGTP-GKP--AIAHRDIKSKNILVKRNGQCAIADFGL 415
            :..||:.:.|:.|..|||.|:||||.:  .|| |:|  .|.|||:||.|||||.:..|.:.||||
Mouse   363 TRHVISWEDLRKLGSSLARGIAHLHSD--HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGL 425

  Fly   416 AVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPV 480
            :::.:..|.|..:|.:.:|||.||||||||..:::.:..|.||:.|:||:.|||||||.|| ..|
Mouse   426 SLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRC-NAV 489

  Fly   481 SGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPN 545
            ...|     ||..|:...|...|..|.|...|.....||.|||.|.....:..|.:.:.|||..:
Mouse   490 GEVK-----DYEPPFGSKVREHPCVESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHD 549

  Fly   546 PTVRLTALRVKKTLGRLE 563
            |..||||..|.:....||
Mouse   550 PEARLTAQCVAERFSELE 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	25/106 (24%)
		GS	238..266	CDD:197743	3/27 (11%)
		STKc_BMPR1	270..562	CDD:271046	123/300 (41%)
Tgfbr2	NP_033397.3	ecTbetaR2	74..177	CDD:462632	27/115 (23%)
		STKc_TGFbR2_like	273..567	CDD:270957	123/301 (41%)