DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and Tgfbr1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_036019848.1	Gene:	Tgfbr1 / 21812	MGIID:	98728	Length:	544	Species:	Mus musculus

Alignment Length:	498	Identity:	236/498 - (47%)
Similarity:	304/498 - (61%)	Gaps:	46/498 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 SLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDET---------TGMYEEERTYGCMPPEDN 135
            :|.|:|.....||.   ||||  .|.||.:|.:..|:.         ..:...:|.:.|.|..
Mouse    70 ALQCFCHLCTKDNF---TCET--DGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSS-- 127

  Fly   136 GGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLTTPAPDL-PVSSESLHTLAVFGSII 199
                  |..||...:     ||: :|.||:...||..|.....:..| ||     ...||....:
Mouse   128 ------KTGAVTTTY-----CCN-QDHCNKIELPTTGPFSEKQSAGLGPV-----ELAAVIAGPV 175

  Fly   200 ISLSVFMLIVASLCF---TYKRREKLRKQPRLINSMCNSQLSPLSQLVEQ--SSGSGSGLPLLVQ 259
            ..:.:.::::..:|.   ....|....:.|.|..... |:.:.|..|:..  :||||||||||||
Mouse   176 CFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFI-SEGTTLKDLIYDMTTSGSGSGLPLLVQ 239

  Fly   260 RTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFI 324
            ||||:.|.:...:||||:||||..|||.|.||||.|.:.||.|||||.||||||::||:||||||
Mouse   240 RTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFI 304

  Fly   325 AADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPA 389
            |||.|.||:|||:.|::||||.|||.|||:...:..:.:..||.|.||||||||.||.||.||||
Mouse   305 AADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPA 369

  Fly   390 IAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQF 454
            |||||:||||||||:||.|.|||.||||:::|..|.|.||.|.||||:||||||||...::.|.|
Mouse   370 IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHF 434

  Fly   455 EEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRP 519
            |.|||||:|::|||.||:.|||  .:.|..    |||.|||:|:|||||:.|:|..|||.:..||
Mouse   435 ESFKRADIYAMGLVFWEIARRC--SIGGIH----EDYQLPYYDLVPSDPSVEEMRKVVCEQKLRP 493

  Fly   520 PIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            .||:|||..:.|..::|||:|||:.|...||||||:||||.:|
Mouse   494 NIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQL 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	26/98 (27%)
		GS	238..266	CDD:197743	18/29 (62%)
		S_TKc	267..557	CDD:214567	174/289 (60%)
		STKc_BMPR1	270..562	CDD:271046	178/291 (61%)
Tgfbr1	XP_036019848.1	Activin_recp	82..147	CDD:395845	21/83 (25%)
		TGF_beta_GS	217..244	CDD:400699	17/26 (65%)
		STKc_TGFbR1_ACVR1b_ACVR1c	250..537	CDD:271045	179/293 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820