Protein Alignment tkv and daf-4

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_498211.1
• Gene: daf-4 / 175781
• WormBaseID: WBGene00000900
• Length: 744
• Species: Caenorhabditis elegans
• Alignment Length: 629
• Identity: 175/629 - (27%)
• Similarity: 279/629 - (44%)
• Gaps: 161/629 - (25%)

  Fly    16 TADGLFEEIALEALTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKTVENARS 80
            |.|...:.|..|| ...|::..:   |..:|.:..:|....|.|........|||:.:.:    |
 Worm    31 TEDDRQDRIESEA-AEKEWANTL---VSKVAQSNGTGTIKVSAPAKPTLRRMDNEEDEVI----S 87

  Fly    81 LTC--YCDGSCPDNVSNGTCE-TRPGGSCFS----------AVQQLYDETTGMYE--------EE 124
            :.|  |.:..|.   .:|.|| |:.  :|:|          ||..|..:.....|        :.
 Worm    88 IECVYYDEMECE---KSGDCEITKK--TCYSEAHLKAVGCLAVFGLPTQEINSTEPYLKVDKPQY 147

  Fly   125 RTYGCMPPED------------------NGGFLMCKVAAVPHLHGKNIVCCDKEDFCNR-DLYPT 170
            ::.||||.:.                  .||..||              ||...: ||. ||...
 Worm   148 KSLGCMPYQHADSMNCENESSCRQGRSFRGGIGMC--------------CCSTNN-CNMPDLIEM 197

  Fly   171 YTPKL------------TTPA-PDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTY------ 216
            ..|.|            :||: .||    |||.....:..|||:||| :|.:|.|...|
 Worm   198 VNPSLKKDSDNSALLWASTPSNMDL----ESLDKFPFYWIIIIALSV-ILCIALLILAYVGWKFQ 257

  Fly   217 -KRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGSG-LPLLVQRTIAKQIQMV---------- 269
             .::|:::||.::...|            |::....:| :||:...  .:.|:||
 Worm   258 QNKKEEIKKQQKIKFDM------------EKTDALEAGNVPLVEPE--EEMIEMVETPKELPITD 308

  Fly   270 -RLVGKGRYGEVWLAKWRDER-----VAVKTFFTTEEASWFRETEIYQTV---LMRHDNILGFIA 325
             :|:.|||:|:|:.|::..:.     ||||.....::||:..|..|:..:   ...:.:|:.|:.
 Worm   309 FQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVC 373

  Fly   326 ADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDE---IFGTPGK 387
            |:..|:..|    ::|::||..||::.|..:||:......:..|:..||..|||:   .||.|.|
 Worm   374 AEKIGDEYW----IVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHPKK 434

  Fly   388 PAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVL--SQQLD 450
            | |.||||||||||||.:....|||||||..|:.:::...:.  .:|||:|||:||:|  :.:..
 Worm   435 P-IIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLL--GQVGTKRYMSPEMLEGATEFT 496

  Fly   451 PKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTK---TTTCEDYALPYHDVVPSDPTFEDMHAVV 512
            |   ..||..|:||:|||:||:       :|.||   |....:|.:|: .|:..|||...|...|
 Worm   497 P---TAFKAMDVYSMGLVMWEV-------ISRTKLHQTDEPPNYQMPF-QVIGFDPTIGLMRNYV 550

  Fly   513 CVKGFRPPIPSRWQED----DVLATVSKIMQECWHPNPTVRLTA 552
            ..|..||    :|:::    :.::.:.|:.:|.|.|....|:||
 Worm   551 VSKKERP----QWRDEIIKHEYMSLLKKVTEEMWDPEACARITA 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	27/127 (21%)
		GS	238..266	CDD:197743	4/28 (14%)
		STKc_BMPR1	270..562	CDD:271046	103/303 (34%)
daf-4	NP_498211.1	TFP_LU_ECD_Daf4	86..192	CDD:467137	26/129 (20%)
		Protein Kinases, catalytic domain	310..603	CDD:473864	103/303 (34%)