Protein Alignment tkv and sma-6

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: NP_495271.1
• Gene: sma-6 / 174044
• WormBaseID: WBGene00004860
• Length: 636
• Species: Caenorhabditis elegans
• Alignment Length: 551
• Identity: 194/551 - (35%)
• Similarity: 291/551 - (52%)
• Gaps: 84/551 - (15%)

  Fly    83 CYCD---GSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGG--FLMCK 142
            |||:   ..|.:|:   ||..:.|.:|:.||:::|::.....|....:||...|...|  .|.|.
 Worm    68 CYCNYDQSICGNNM---TCVKQDGAACYHAVEEVYNKAEKRMETLHKWGCATLERGSGASHLTCN 129

  Fly   143 VAAVPHLHGKNIVCCDKEDFCNRDLYPT-----YTPKLTTPAPDLPVSSES-LHTLAVFGSIIIS 201
            .....|...|:|.||.:.::||::|.|.     :..|......|.|...:| |..:...|.:.|.
 Worm   130 SWRAAHHSPKSIGCCYEGNYCNKNLIPPAYVHHHKEKALQEKTDNPEDYDSPLENMTRGGKMFIM 194

  Fly   202 -----LSVFMLI-VASLCFT-YKRREKLRKQPRLINSMCNSQLSPLSQLVEQSSGSGSGLPLLVQ 259
                 :|||.:| ...||.| .:.:.|.|.:.:.::....|.......::| .||||||...|:|
 Worm   195 VFATVMSVFAVIGCIYLCITRAEEKSKARARAKTVSLKTESTYMESKSMLE-DSGSGSGQAALIQ 258

  Fly   260 RTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFI 324
            ||:.:.:.:::.:|:||||||..|.:|...||||||:||:|.||..|.::|||.::.|:|||.|:
 Worm   259 RTVRQDLTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFV 323

  Fly   325 AADI-KGNGSWTQMLLITDYHEMGSLHDYL--SMSVINPQKLQLLAFSLASGLAHLHDEIFGTPG 386
            |||| ....|.|:|||||||||:|||.|||  ..::...:.|:|: .|...|:.|||..:.||..
 Worm   324 AADIWSEEDSMTKMLLITDYHELGSLSDYLCREETLTTDEALRLI-HSCICGIEHLHAAVHGTGS 387

  Fly   387 --KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQL 449
              ||.|||||||||||:|||...|.|||.|||::|.:: .::....|.:|||:||||||::|.:|
 Worm   388 FRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQND-KILPEKFNVQVGTKRYMAPELISNKL 451

  Fly   450 DPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCED------------------------ 490
            :||.|.:||.||:||:.||:||:..|       .:..|||:
 Worm   452 NPKDFSQFKMADIYSMALVMWEVAIR-------VEVNTCEEVLTVDETSPDHSASSGIGESVSSS 509

  Fly   491 ------------------------YALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVL 531
                                    :..|:..:|.:||.|::|:.|:||:..|||....|:....|
 Worm   510 GNISRMHLQKTNVEGHSTSLKAKQHVPPFDGIVHNDPNFDEMNDVICVRRIRPPPDLAWKNVPAL 574

  Fly   532 ATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            ..:||:|::.||..|..|.:||::||.:..|
 Worm   575 NELSKLMEDSWHSIPHFRHSALKLKKEMAEL 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	27/90 (30%)
		GS	238..266	CDD:197743	11/27 (41%)
		STKc_BMPR1	270..562	CDD:271046	137/344 (40%)
sma-6	NP_495271.1	TFP_LU_ECD_sma6	66..153	CDD:467116	26/87 (30%)
		GS	238..265	CDD:197743	11/27 (41%)
		STKc_TGFbR_I	269..605	CDD:270958	137/344 (40%)