DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tkv and Acvrl1

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001264184.1	Gene:	Acvrl1 / 11482	MGIID:	1338946	Length:	517	Species:	Mus musculus

Alignment Length:	502	Identity:	227/502 - (45%)
Similarity:	298/502 - (59%)	Gaps:	66/502 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 PDNVSNGTCET----RP---GGSCFSAV-------QQLYDETTGMYEEERTYGCMPPEDNGGFLM 140
            |..:.|.|||:    ||   |..|...:       .|:| ...|...:|...| .|.|    ||
Mouse    42 PSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQVY-RGCGSLNQELCLG-RPTE----FL- 99

  Fly   141 CKVAAVPHLHGKNIVCCDKEDFCNRD----LYPTYTPKLTTPAPDLPVSSESLHTLAVFGSIIIS 201
                        |..||.: .|||.:    |..|.||   :..|::     ..|...:.|. :::
Mouse   100 ------------NHHCCYR-SFCNHNVSLMLEATQTP---SEEPEV-----DAHLPLILGP-VLA 142

  Fly   202 LSVFMLIVASLCFTYKRREKLRKQPRLINSMCNSQL---------SPLSQLVEQ--SSGSGSGLP 255
            |.|.:.:.|...:..:||::  ||..|.:.:..|.|         |.|...::.  ::|||||||
Mouse   143 LPVLVALGALGLWRVRRRQE--KQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLP 205

  Fly   256 LLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNI 320
            .|||||:|:|:.:|..||||||||||...|..|.||||.|.:.:|.|||||||||.|||:|||||
Mouse   206 FLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNI 270

  Fly   321 LGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTP 385
            |||||:|:....|.||:.|||.|||.|||:|:|....:.||....||.|.|.||||||.|||||.
Mouse   271 LGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQ 335

  Fly   386 GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLD 450
            |||||||||:||:|:|||.|.||.|||.||||.::...|.:.|..||||||:||||||||.:.:.
Mouse   336 GKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIR 400

  Fly   451 PKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVK 515
            ...||.:|..|:::.||||||:.||  |.::|    ..|||..|::|:||:||:||||..||||.
Mouse   401 TDCFESYKWTDIWAFGLVLWEIARR--TIING----IVEDYRPPFYDMVPNDPSFEDMKKVVCVD 459

  Fly   516 GFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTLGRL 562
            ...|.||:|...|.||:.::::|:|||:|||:.||||||:||||.:|
Mouse   460 QQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	25/98 (26%)
		GS	238..266	CDD:197743	15/29 (52%)
		S_TKc	267..557	CDD:214567	165/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	168/291 (58%)
Acvrl1	NP_001264184.1	LU	48..112	CDD:299177	22/83 (27%)
		TGF_beta_GS	187..214	CDD:285687	13/26 (50%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	174/303 (57%)
		Pkinase_Tyr	216..503	CDD:285015	167/292 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750