DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and Acvr1b

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_031421.1	Gene:	Acvr1b / 11479	MGIID:	1338944	Length:	505	Species:	Mus musculus

Alignment Length:	535	Identity:	244/535 - (45%)
Similarity:	316/535 - (59%)	Gaps:	68/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDETTGM 120
            ||||                ...::|.|.|. ||..  :|.||||  .|:|..::..|    .|:
Mouse    23 GSGP----------------RGIQALLCACT-SCLQ--TNYTCET--DGACMVSIFNL----DGV 62

  Fly   121 YEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKE----------DFCNRDLYPTYTPKL 175
            ....||  |:|          ||..||  .||...|...|          ||||:......:..|
Mouse    63 EHHVRT--CIP----------KVELVP--AGKPFYCLSSEDLRNTHCCYIDFCNKIDLRVPSGHL 113

  Fly   176 TTPA-PDL--PVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKL-RKQPRLINSMCNSQ 236
            ..|| |.:  ||....:....||...:|.:.|| |::......|..|::| .:.|..  .||.|:
Mouse   114 KEPAHPSMWGPVELVGIIAGPVFLLFLIIIIVF-LVINYHQRVYHNRQRLDMEDPSC--EMCLSK 175

  Fly   237 LSPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTE 299
            ...|..||.  .:|||||||||.||||:|:.|.:..::||||:||||..:||...||||.|.:.|
Mouse   176 DKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSRE 240

  Fly   300 EASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQ 364
            |.|||||.||||||::||:|||||||||.|.||:|||:.|::||||.|||.|||:...:..:.:.
Mouse   241 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMI 305

  Fly   365 LLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIA 429
            .||.|.||||||||.||.||.|||.|||||:||||||||:||.|||||.||||::::..|.|.||
Mouse   306 KLALSAASGLAHLHMEIVGTQGKPGIAHRDLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIA 370

  Fly   430 QNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALP 494
            .|.||||:||||||||.:.::.|.|:.||.||:|::|||.||:.|||.:  .|..    |||.||
Mouse   371 PNQRVGTKRYMAPEVLDETINMKHFDSFKCADIYALGLVYWEIARRCNS--GGVH----EDYQLP 429

  Fly   495 YHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTL 559
            |:|:|||||:.|:|..|||.:..||.:|:.||..:.|..:.|:|:|||:.|...||||||:||||
Mouse   430 YYDLVPSDPSIEEMRKVVCDQKLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL 494

  Fly   560 GRLETDCLIDVPIKI 574
            .:|.    :...:||
Mouse   495 SQLS----VQEDVKI 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	30/99 (30%)
		GS	238..266	CDD:197743	17/29 (59%)
		S_TKc	267..557	CDD:214567	166/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	170/291 (58%)
Acvr1b	NP_031421.1	Activin_recp	32..109	CDD:279413	30/99 (30%)
		TGF_beta_GS	178..205	CDD:285687	16/26 (62%)
		S_TKc	209..492	CDD:214567	166/288 (58%)
		STKc_TGFbR1_ACVR1b_ACVR1c	211..498	CDD:271045	170/292 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750