DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and acvr1c

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	XP_002933316.2	Gene:	acvr1c / 100487548	XenbaseID:	XB-GENE-487108	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	536	Identity:	230/536 - (42%)
Similarity:	310/536 - (57%)	Gaps:	88/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 ENARSLTCYCDGSCP------------------------------DNVSNGTCETRPGGSCFSAV 110
            :..|...|.|.|:.|                              :| :|.||:|.  |:|:::|
Frog    33 QGPRYCLCRCGGNMPGAGLLTLGAALILLSAASLCSGLKCVCLLCEN-TNYTCQTE--GACWTSV 94

  Fly   111 QQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIV----CCDKEDFCNRDLYPTY 171
            ...:.      :||....|:...:....:.|        |..|.:    || ..||||     ..
Frog    95 MLTHG------KEEVLKSCISLPEFKAQVFC--------HSSNNITRTECC-LSDFCN-----NI 139

  Fly   172 TPKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLC-FTYKRREKLRKQPRLINSMCNS 235
            |.:|....|.:........|:.|..||.: |||.:::.|.:| ..|..:.|.|:|       |..
Frog   140 TLRLPAVTPGVSHMGHVELTVIVTVSICL-LSVVIMVTAYVCQERYCAKNKARRQ-------CVE 196

  Fly   236 QLSPLSQ------------LVEQ--SSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWR 286
            :  ||::            |:..  :||||||||||||||||:.:.:..||||||:||||..||.
Frog   197 E--PLTECPLDIAGKSLKDLIYDMTTSGSGSGLPLLVQRTIARTVVIQELVGKGRFGEVWRGKWC 259

  Fly   287 DERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHD 351
            .|.||||.|.:.:|.|||||.||||||::||:|||||||||.|.||:|||:.||:::||.|||.|
Frog   260 GEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLISEFHEQGSLFD 324

  Fly   352 YLSMSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLA 416
            ||:.:.:....:..||.|:.|||||||.||.||.|||||||||:||||||||:|..|.|||.|||
Frog   325 YLNCNTVTIGGMMKLALSVVSGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNETCCIADLGLA 389

  Fly   417 VKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVS 481
            ||::|..:.|.|.|||||||:||||||:|...::...|:.||.:|:||:|||.||:.|||  .|.
Frog   390 VKHDSITNTIDIPQNPRVGTKRYMAPELLDDSINTYHFDSFKCSDIYSLGLVYWEIARRC--SVG 452

  Fly   482 GTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNP 546
            |    ..::|.|||:|:|||||:.||:..|||.:..||.||::||..:.|..:.:||:|||:.|.
Frog   453 G----VVDEYQLPYYDMVPSDPSLEDVRKVVCEQKLRPSIPNQWQSFEALRIMGRIMRECWYANG 513

  Fly   547 TVRLTALRVKKTLGRL 562
            ..||||||:|||:.:|
Frog   514 KARLTALRIKKTISQL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	24/123 (20%)
		GS	238..266	CDD:197743	19/41 (46%)
		S_TKc	267..557	CDD:214567	165/289 (57%)
		STKc_BMPR1	270..562	CDD:271046	168/291 (58%)
acvr1c	XP_002933316.2	Activin_recp	70..139	CDD:366445	20/91 (22%)
		TGF_beta_GS	210..237	CDD:369918	16/26 (62%)
		STKc_TGFbR1_ACVR1b_ACVR1c	243..530	CDD:271045	169/293 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920