Protein Alignment tkv and tgfbr2a

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_073787446.1
• Gene: tgfbr2a / 100334928
• ZFINID: ZDB-GENE-120404-1
• Length: 659
• Species: Danio rerio
• Alignment Length: 581
• Identity: 181/581 - (31%)
• Similarity: 263/581 - (45%)
• Gaps: 106/581 - (18%)

  Fly    10 LQATSGTADGLFEEIALEALTRSEFSANVQPDVEAMAAAALSGMEMGSGPGSEGYEDADNEKSKT 74
            |:..|.|.|...:.:.|..||..|                    ::.....|.|:....|.|...
Zfish   113 LRVCSCTGDQCNQNLLLRKLTEEE--------------------KLSKTNSSSGFRLKQNCKFCD 157

  Fly    75 VENARSLTCYCDGSCPDNVS-NGTCETRPGGSCFSAVQQLYDETTGMYEEERTYGCMPPEDNGGF 138
            ||   |..|...|.|..... |..||| |...|.||.:                      .|||
Zfish   158 VE---SSVCNASGVCESACGINSICET-PDEVCASAWR----------------------SNGG- 195

  Fly   139 LMCKVAAVPH-----LHGKNI------------------VCCDKEDFCNRDLYPTYTPKLTTPAP 180
             ...:..|.|     .||.|:                  :|...::.||..|:..:..|......
Zfish   196 -NSSIETVCHNPALLFHGHNLTDSQSRVCQMRRVEEDLYICSCNDEECNDRLFFNHDLKQYPGVQ 259

  Fly   181 DLPVSSESLHTLAVFGSIIISLSVFMLI---VASLCFTY---KRREKLRKQPRLINSMCNSQLSP 239
            ..|.|..|..:||.     :.:|||:||   :.|:.:.|   :.:.||..:..|.:..||..::|
Zfish   260 FDPPSESSWFSLAP-----VLISVFVLIPIVLLSVFYCYHISQHKLKLPNKKSLDSERCNIFMNP 319

  Fly   240 LSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRD-----ERVAVKTFFTTE 299
                .|.|..|......|...|....||:.|:|||||:.:|:.||.:.     :.||||.|...|
Zfish   320 ----EEHSDSSSINANSLNHNTELLPIQLDRVVGKGRFADVYKAKLKQSADSFQTVAVKIFPYEE 380

  Fly   300 EASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQ 364
            .:||..|.:|:..|.:||:|:|.|:.|:.:  .:..|..|||.|||.|:|.:.|::.||..:::.
Zfish   381 FSSWKSEWQIFSDVELRHENVLQFLTAEER--TAERQYWLITAYHERGNLQELLALQVIGWEEMC 443

  Fly   365 LLAFSLASGLAHLHDEIFGTP---GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVI 426
            .|..|||.|:||||.:  .||   .|.:|||||:||.|:|||.:..|.:.||||:::.:|.|...
Zfish   444 RLGVSLARGVAHLHSD--RTPCGRAKVSIAHRDLKSSNVLVKSDWSCCVCDFGLSLRLDSCLSPE 506

  Fly   427 HIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDY 491
            .:|.:.:|||.||||||||..::|.:..|.||:||:||:.|||||:..||      :.|....||
Zfish   507 ELANSGQVGTARYMAPEVLESRMDLENTESFKQADVYSMALVLWEIMSRC------SATGDVRDY 565

  Fly   492 ALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA 552
            ..|: ..:...|..|.|...|.....||.||:.|.:...:..:|..::|||..:|..||||
Zfish   566 EPPF-GKLKGHPCVESMKDDVIRDRLRPEIPTSWSKHAGVHHLSSTIEECWDHDPEARLTA 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	23/111 (21%)
		GS	238..266	CDD:197743	6/27 (22%)
		STKc_BMPR1	270..562	CDD:271046	117/291 (40%)
tgfbr2a	XP_073787446.1	None