Protein Alignment tkv and acvr2a

DIOPT Version :10

• Sequence 1: NP_787990.1
• Gene: tkv / 33753
• FlyBaseID: FBgn0003716
• Length: 575
• Species: Drosophila melanogaster
• Sequence 2: XP_017952544.1
• Gene: acvr2a / 100216172
• XenbaseID: XB-GENE-484012
• Length: 521
• Species: Xenopus tropicalis
• Alignment Length: 545
• Identity: 178/545 - (32%)
• Similarity: 273/545 - (50%)
• Gaps: 82/545 - (15%)

  Fly    51 SGMEMGSGPGSE-GYEDADNEKSKTVENARSLTCYCDG-------SCPDNVSNGTCETRPGGSCF 107
            ||..:|.....| .|.:|:.||.||..|...: ||.|.       :...|:| |:.|....| |:
 Frog    18 SGAILGRSETKECVYYNANWEKDKTNPNGTEI-CYGDNDKRRHCFATWKNIS-GSIEIVKQG-CW 79

  Fly   108 SAVQQLYDETTGMYEEERTYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYT 172
            ......||::          .|...:::.....|              ||: .:.||...|.:..
 Frog    80 LDDMNCYDKS----------DCTERKESPDVFFC--------------CCE-GNTCNERFYHSPE 119

  Fly   173 PKLTTPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTY--KRREKLRKQPRLINSMCNS 235
            .::|.|..: ||.::.    .:|.:::.||...|::...:.|::  .|..||...|.|:.:
 Frog   120 MEVTQPTSN-PVPTKP----PLFNTLLYSLVPIMVVAVIVLFSFWMYRHHKLAYPPVLVPT---- 175

  Fly   236 QLSPLSQLVEQSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEE 300
              .....::.:..|.....|||.    .|.:|::.:..:||:|.||.|:..:|.||||.|...::
 Frog   176 --QHAFHIMIEDPGPPPPSPLLG----LKPLQLLEVKARGRFGCVWKAQLLNETVAVKIFPIQDK 234

  Fly   301 ASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQL 365
            .||..|.|||....|:|:|||.||.|:.:|....|.:.|||.:||.|||.|||..:|::..:|..
 Frog   235 LSWQNEYEIYNLPGMKHENILQFIGAEKRGTNLDTDLWLITAFHEKGSLTDYLKANVVSWNELCH 299

  Fly   366 LAFSLASGLAHLHDEIFGTPG-----KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKY---NSE 422
            :|.::|.|||:||::|   ||     |||:|||||||||||:|.:....|||||||:|:   .|.
 Frog   300 IAETMARGLAYLHEDI---PGLKDGHKPAVAHRDIKSKNILLKNSLTACIADFGLALKFEAGKSA 361

  Fly   423 LDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTT 487
            .|.     :.:||||||||||||...:: .|.:.|.|.|||:.||||||:..|| |...|    .
 Frog   362 GDT-----HGQVGTRRYMAPEVLEGAIN-FQRDAFLRIDMYAFGLVLWELASRC-TASDG----P 415

  Fly   488 CEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA 552
            .::|.||:.:.|...|:.|||..||..|..||.:...||:...:|.:.:.::|||..:...||:|
 Frog   416 VDEYMLPFEEEVGQHPSLEDMQEVVVHKKKRPILRECWQKHAGMAMLCETIEECWDHDAEARLSA 480

  Fly   553 -------LRVKKTLGRLETDCLIDV 570
                   ::::|....:.|:.::.|
 Frog   481 GCVEERIIQMQKLTNIITTEDIVTV 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	TFP_LU_ECD_Tkv	81..169	CDD:467125	17/94 (18%)
		GS	238..266	CDD:197743	5/27 (19%)
		STKc_BMPR1	270..562	CDD:271046	127/306 (42%)
acvr2a	XP_017952544.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	26/121 (21%)
		STKc_ACVR2a	204..493	CDD:271043	126/302 (42%)