DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tkv and bmpr1bb

DIOPT Version :9

Sequence 1:	NP_787990.1	Gene:	tkv / 33753	FlyBaseID:	FBgn0003716	Length:	575	Species:	Drosophila melanogaster
Sequence 2:	NP_001139468.1	Gene:	bmpr1bb / 100149664	ZFINID:	ZDB-GENE-090610-1	Length:	535	Species:	Danio rerio

Alignment Length:	523	Identity:	265/523 - (50%)
Similarity:	336/523 - (64%)	Gaps:	44/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 MEMGSGPGSEGYEDADNEKSKTVENARSLTCYCDGSCPDNVSNGTCETRPGGSCFSAVQQLYDET 117
            ::..||..:.|.::.:...:.:|...|.|.|:|...||::.:|.||.|  .|.||:
Zfish    36 LQRSSGKVTAGRKETNGGSATSVIPERMLLCHCYHHCPEDSTNNTCRT--DGYCFT--------- 89

  Fly   118 TGMYEEER------TYGCMPPEDNGGFLMCKVAAVPHLHGKNIVCCDKEDFCNRDLYPTYTPKLT 176
              |.|||.      |.||:...  |....|:......|. :.:.||..:|:||:||:|| .|.|.
Zfish    90 --MAEEEEGGSPVLTSGCLSLV--GSEFQCRDTGNARLR-RILECCTDQDYCNQDLHPT-LPPLK 148

  Fly   177 TPAPDLPVSSESLHTLAVFGSIIISLSVFMLIVASLCFTYKRREKLRKQPRLINSMCNSQL---- 237
            ||..|     .|:|..|:..|.::|..:..:|:....|.|:|:   ..|.|....:...:.
Zfish   149 TPDVD-----SSVHYTALLISAMLSFIILGVIMFYCYFRYRRQ---GTQTRYSMGLEQDESFIPA 205

  Fly   238 -SPLSQLVE--QSSGSGSGLPLLVQRTIAKQIQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTE 299
             ..|..|:|  ||||||||||||||||||||||||:.:|||||||||:.:||.||||||.|||||
Zfish   206 GESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGRWRGERVAVKVFFTTE 270

  Fly   300 EASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQ 364
            ||||||||||||||||||:||||||||||||.|||||:.|||||||.|||:|||..:.::.:.|.
Zfish   271 EASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHESGSLYDYLKSTTLDTRALL 335

  Fly   365 LLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIA 429
            .|::|..|||.|||.|||||.|||||||||:||||||||:|..|.|||.|||||:.|:.:.:.|.
Zfish   336 RLSYSAVSGLCHLHTEIFGTQGKPAIAHRDLKSKNILVKKNSTCCIADLGLAVKFISDTNEVDIP 400

  Fly   430 QNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALP 494
            .|.||||:|||.||||.:.|:...|:.:..|||||.||:|||::|||   |||   ...|:|.||
Zfish   401 PNTRVGTKRYMPPEVLDESLNRCHFQSYIMADMYSFGLILWEISRRC---VSG---GIMEEYQLP 459

  Fly   495 YHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTL 559
            |||:|||||::|||..|||:|..||...:||..|:.|..:.|:|.|||..||..|||||||||||
Zfish   460 YHDLVPSDPSYEDMREVVCIKRQRPSFANRWSSDECLRQMGKLMSECWAHNPASRLTALRVKKTL 524

  Fly   560 GRL 562
            .::
Zfish   525 AKM 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tkv	NP_787990.1	Activin_recp	81..171	CDD:279413	30/95 (32%)
		GS	238..266	CDD:197743	22/29 (76%)
		S_TKc	267..557	CDD:214567	185/289 (64%)
		STKc_BMPR1	270..562	CDD:271046	186/291 (64%)
bmpr1bb	NP_001139468.1	Activin_recp	64..144	CDD:279413	31/96 (32%)
		PKc_like	231..535	CDD:304357	196/303 (65%)
		S_TKc	238..522	CDD:214567	185/289 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577730
Domainoid	1	1.000	59	1.000	Domainoid score	I10628
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	483	1.000	Inparanoid score	I1407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D338017at33208
OrthoFinder	1	1.000	-	-		FOG0000203
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105740
Panther	1	1.100	-	-	O	PTHR23255
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.900