Protein Alignment TpnC25D and CALM3

DIOPT Version :10

• Sequence 1: NP_608915.2
• Gene: TpnC25D / 33752
• FlyBaseID: FBgn0031692
• Length: 149
• Species: Drosophila melanogaster
• Sequence 2: NP_005175.2
• Gene: CALM3 / 808
• HGNCID: 1449
• Length: 149
• Species: Homo sapiens
• Alignment Length: 146
• Identity: 51/146 - (34%)
• Similarity: 97/146 - (66%)
• Gaps: 3/146 - (2%)

  Fly     4 DEKMDIMRKAFQMFDTQKTGFIETLRLKTILNSMGQMFDDSELQALIDDNDPEDTGKVNFDGFCS 68
            :|::...::||.:||....|.|.|..|.|::.|:||...::|||.:|::.|.:..|.::|..|.:
Human     7 EEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLT 71

  Fly    69 IAAHFLEEEDAEAIQKELKEAFRLYDREGNGYITTSTLKEILAALDDKLSSSDLDGIIAEIDTDG 133
            :.|..:::.|:|   :|::||||::|::|||||:.:.|:.::..|.:||:..::|.:|.|.|.||
Human    72 MMARKMKDTDSE---EEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDG 133

  Fly   134 SGTVDFDEFMEMMAGE 149
            .|.|:::||::||..:
Human   134 DGQVNYEEFVQMMTAK 149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TpnC25D	NP_608915.2	PTZ00184	4..146	CDD:185504	49/141 (35%)
CALM3	NP_005175.2	PTZ00184	1..149	CDD:185504	51/144 (35%)
		Necessary and sufficient for interaction with PCP4. /evidence=ECO:0000269|PubMed:27876793	77..149		29/74 (39%)