DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14034 and LPL

DIOPT Version :9

Sequence 1:	NP_001036339.1	Gene:	CG14034 / 33751	FlyBaseID:	FBgn0250847	Length:	338	Species:	Drosophila melanogaster
Sequence 2:	NP_000228.1	Gene:	LPL / 4023	HGNCID:	6677	Length:	475	Species:	Homo sapiens

Alignment Length:	276	Identity:	79/276 - (28%)
Similarity:	125/276 - (45%)	Gaps:	36/276 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 FYHHKPLKVLIHGF---NGHRDFSPNTQLRPLFLTQDYNLISLDYPKLAYEPCYTEAVHNAKYVA 124
            |.|.....::|||:   ..:..:.|...........|.|:|.:|:...|.|. |..:....|.|.
Human    69 FNHSSKTFMVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEH-YPVSAGYTKLVG 132

  Fly   125 RCTAQLLRVLLESGLVKIEDLHLIGLGLGAHVAGFIGQFLPEHKLEHITALDPAKPFYMVKDPAL 189
            :..|:.:..:.|.....::::||:|..||||.||..|. |...|:..||.||||.|.:...:...
Human   133 QDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGS-LTNKKVNRITGLDPAGPNFEYAEAPS 196

  Fly   190 KLDPTDAKFVDVVHTDV-----TMLGLLDAVGHVDFYLNMGVSQPNC--------------GPIN 235
            :|.|.||.||||:||..     ..:|:...|||||.|.|.|..||.|              |.::
Human   197 RLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQPGCNIGEAIRVIAERGLGDVD 261

  Fly   236 KMETHFCYHNRAADYYAESI---SSPSGFYGFYCPNFKSFAKGICIP-DKN-IELMGFHVD---P 292
            ::..  |.|.|:...:.:|:   .:||..|  .|.:.::|.||:|:. .|| ...:|:.::   .
Human   262 QLVK--CSHERSIHLFIDSLLNEENPSKAY--RCSSKEAFEKGLCLSCRKNRCNNLGYEINKVRA 322

  Fly   293 KARGRYFLDTNNGPPY 308
            |...:.:|.|.:..||
Human   323 KRSSKMYLKTRSQMPY 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14034	NP_001036339.1	Pancreat_lipase_like	37..303	CDD:238363	76/269 (28%)
LPL	NP_000228.1	Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:30559189	32..53
		Lipase	33..473	CDD:332983	79/276 (29%)
		Essential for determining substrate specificity. /evidence=ECO:0000269\|PubMed:7592706	243..266		2/24 (8%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000269\|PubMed:27929370	417..421
		Important for heparin binding. /evidence=ECO:0000269\|PubMed:11342582	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000269\|PubMed:26725083, ECO:0000269\|PubMed:30559189	443..467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010