Protein Alignment CG7742 and TBC1D19

DIOPT Version :9

• Sequence 1: NP_001285615.1
• Gene: CG7742 / 33750
• FlyBaseID: FBgn0031690
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_016863852.1
• Gene: TBC1D19 / 55296
• HGNCID: 25624
• Length: 528
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 210/549 - (38%)
• Similarity: 319/549 - (58%)
• Gaps: 74/549 - (13%)

  Fly     1 MEELQDASIHHMTAKVIAAIKNTKSYEPIYKELQKLVCNPSVDTHDMRNTLEDAIKSAGLETEIR 65
            ::|..|.|:  :.|:::..:|.:..|..:.::....:..|.:....::..:::..|.:|.|.:::
Human     2 LQEESDLSL--IIAQIVQKLKGSNLYSQLERQAWASLQRPEIKLESLKEDIKEFFKISGWEKKLQ 64

  Fly    66 NIVYNLVRTRLSKTDDKNLANKQGAKPT-VSDPLGYLKRAGVLWDRRVRKSLNAMCTELKVPLHG 129
            |.||       |:.....|.:...|.|. :.:||.|:::|...|::|:.||||:|||||.:|| .
Human    65 NAVY-------SELSVFPLPSHPAAPPEHLKEPLVYMRKAQGSWEKRILKSLNSMCTELSIPL-A 121

  Fly   130 QPRISADREDFMAKWNELSNYNMDLANYRPVYAPKDLLEVLLSLKGPAKTTENTD---------- 184
            :.|...::::.:.||||:.....||:.:||||||||.||||::|:.|  ..||.|
Human   122 RKRPVGEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLEVLINLRNP--NYENGDSLSFRTHLGL 184

  Fly   185 -QIPQWEFSHIALPVKNLFELRAHYADLLRSDSYLGVPDLT-----------VQC-QRILEARHA 236
             |:|        |.||::.||:..:.:|..:...||:.|.|           |:. |::|..:.:
Human   185 IQVP--------LKVKDIPELKECFVELGLNIGQLGIDDSTQVPPELFENEHVRIGQKVLAEQDS 241

  Fly   237 PMCQQFLKKGCTPAPYRGALWASVLDSKLHDYDIEYWQKLRNAVWTTDHIVDKLVFKDIQLTASN 301
            ...||::::| :|...|..|||.:|:......|:.|:::|:..|...|.:||.|::||::|||||
Human   242 AAAQQYIRQG-SPTALRAELWALILNISSQPEDVLYYEQLKTNVIQHDLLVDSLIYKDVKLTASN 305

  Fly   302 DDQYFVFEDVLYQVLLCFSRDTDI-----------------G--GCVEYETFPVKGKTYEGPPSG 347
            ||.||||||.||||||||||||.:                 |  |..||..|      |  ||:|
Human   306 DDYYFVFEDYLYQVLLCFSRDTSVLSHFAFNSASPPKSYIRGKLGLEEYAVF------Y--PPNG 362

  Fly   348 VVPFHGICMFAAPFCYLYDSPVSLYYTFRAFYIRYCHRLTTINTHPQGIVSLCLLFEKLLQTYEP 412
            |:||||..|:.||.|:||..|..||..||..|:|:..||.:|::||.||||||||||.|||||.|
Human   363 VIPFHGFSMYVAPLCFLYHEPSKLYQIFREMYVRFFFRLHSISSHPSGIVSLCLLFETLLQTYLP 427

  Fly   413 QLWSHFRELQIQPLRVVFKWLMRAFSGHLPPDQLLVLWDLILGFDSLEILPLFAIIILSFRKESI 477
            ||:.|.||:..||||:.|||::|||||:|..||||:|||.|||::|||||.:.|..:.:||..::
Human   428 QLFYHLREIGAQPLRISFKWMVRAFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNL 492

  Fly   478 MQVASLDSIEA--ILADLSSIKVLPLVQL 504
            |:|.||.:.|.  .|.:|.|:.:..:|::
Human   493 MEVTSLAAAEKKNHLRELKSMYLDDIVKI 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7742	NP_001285615.1	TBC	249..478	CDD:214540	125/247 (51%)
TBC1D19	XP_016863852.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159940
Domainoid	1	1.000	149	1.000	Domainoid score	I4452
eggNOG	1	0.900	-	-		E1_28K1A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10130
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2057
Isobase	1	0.950	-	0	Normalized mean entropy	S6260
OMA	1	1.010	-	-		QHG52833
OrthoDB	1	1.010	-	-		D1481068at2759
OrthoFinder	1	1.000	-	-		FOG0008286
OrthoInspector	1	1.000	-	-		oto91167
orthoMCL	1	0.900	-	-		OOG6_106228
Panther	1	1.100	-	-	LDO	PTHR16110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5534
SonicParanoid	1	1.000	-	-		X6268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750