DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7742 and tbc1d19

DIOPT Version :9

Sequence 1:	NP_001285615.1	Gene:	CG7742 / 33750	FlyBaseID:	FBgn0031690	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_956785.1	Gene:	tbc1d19 / 393463	ZFINID:	ZDB-GENE-040426-1265	Length:	526	Species:	Danio rerio

Alignment Length:	536	Identity:	214/536 - (39%)
Similarity:	326/536 - (60%)	Gaps:	46/536 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEELQDASIHHMTAKVIAAIKNTKSYEPIYKELQKLVCNPSVDTHDMRNTLEDAIKSAGLETEIR 65
            |:|..:.|:  ...:::..:|.|..:..:.|:.::.:..|.:....:::.:...:|::|.|.:::
Zfish     2 MDESTELSV--SITQIVQRLKGTHLHSQLEKQAKECLHKPEIKLETLKDDVRRVLKASGWERKLQ 64

  Fly    66 NIVYNLVRTRLSKTDDKNLANKQG---AKPT-VSDPLGYLKRAGVLWDRRVRKSLNAMCTELKVP 126
            |.||.          :.::....|   |.|. ..:||.|:.:|...|::|:.||||:|||||.:|
Zfish    65 NAVYR----------ELHVLPPPGHPRAPPEHTKEPLAYMLKAQASWEKRILKSLNSMCTELGIP 119

  Fly   127 LHGQPRISADREDFMAKWNELSNYNMDLANYRPVYAPKDLLEVLLSLKGPAKTTENTDQI---PQ 188
            | .:.|...::::...||||:.....||:|:||||||||.||||:.|:.|  .||.:|.:   ..
Zfish   120 L-ARKRPVMEQKELTNKWNEMGTDEPDLSNFRPVYAPKDFLEVLIGLRNP--NTERSDDLTVKSH 181

  Fly   189 WEFSHIALPVKNLFELRAHYADLLRSDSYLGVPDLTVQCQRILEARH------------APMCQQ 241
            |....::|.|.::.::|..||:|..|...||:.|.|.....:.|:.|            :...||
Zfish   182 WGLIQVSLNVHDIPQMRETYAELGLSYGQLGIDDHTHVPPDLFESEHIHIGKKVVSEQDSAAAQQ 246

  Fly   242 FLKKGCTPAPYRGALWASVLDSKLHDYDIEYWQKLRNAVWTTDHIVDKLVFKDIQLTASNDDQYF 306
            :.::|| |...|..||:.:|::.....||.::::|:..|...:.:||.|::||::|||||||.||
Zfish   247 YSRQGC-PTGLRAQLWSLILNTTNDPEDITHYEQLKARVIHHNLLVDNLIYKDVKLTASNDDYYF 310

  Fly   307 VFEDVLYQVLLCFSRDTDIGGCVEYET-FPVKG--KTYEG--------PPSGVVPFHGICMFAAP 360
            ||||.||||||||||||.:.....|.: .|.|.  ::..|        ||:||:||||..|:.||
Zfish   311 VFEDYLYQVLLCFSRDTAVLEHFNYNSASPPKSSIQSKSGSEQCAVVYPPNGVIPFHGFSMYVAP 375

  Fly   361 FCYLYDSPVSLYYTFRAFYIRYCHRLTTINTHPQGIVSLCLLFEKLLQTYEPQLWSHFRELQIQP 425
            .|:||:.|..||..||..||||..||.:|::||.|||||||.||:|||.:.|||:.|.||:..||
Zfish   376 LCFLYNEPSKLYSVFREMYIRYFFRLHSISSHPSGIVSLCLQFERLLQAHLPQLFYHLREIGAQP 440

  Fly   426 LRVVFKWLMRAFSGHLPPDQLLVLWDLILGFDSLEILPLFAIIILSFRKESIMQVASLDSIEAIL 490
            ||:.|||::|||||:|..||||:|||.|||::||||:.:.|..:.:||.|::|:|.||.|.||:|
Zfish   441 LRIAFKWIVRAFSGYLSTDQLLLLWDRILGYNSLEIVAVLATAVFAFRAENLMEVTSLASAEAVL 505

  Fly   491 ADLSSIKVLPLVQLAL 506
            ||||::||:||:|:.|
Zfish   506 ADLSTLKVMPLLQIFL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7742	NP_001285615.1	TBC	249..478	CDD:214540	120/239 (50%)
tbc1d19	NP_956785.1	TBC	248..466	CDD:214540	109/218 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596227
Domainoid	1	1.000	151	1.000	Domainoid score	I4338
eggNOG	1	0.900	-	-		E1_28K1A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10130
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1987
OMA	1	1.010	-	-		QHG52833
OrthoDB	1	1.010	-	-		D1481068at2759
OrthoFinder	1	1.000	-	-		FOG0008286
OrthoInspector	1	1.000	-	-		oto40903
orthoMCL	1	0.900	-	-		OOG6_106228
Panther	1	1.100	-	-	LDO	PTHR16110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5534
SonicParanoid	1	1.000	-	-		X6268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800