DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7742 and Tbc1d19

DIOPT Version :9

Sequence 1:	NP_001285615.1	Gene:	CG7742 / 33750	FlyBaseID:	FBgn0031690	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001099478.1	Gene:	Tbc1d19 / 289657	RGDID:	1304958	Length:	526	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	218/543 - (40%)
Similarity:	330/543 - (60%)	Gaps:	60/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEELQDASIHHMTAKVIAAIKNTKSYEPIYKELQKLVCNPSVDTHDMRNTLEDAIKSAGLETEIR 65
            ::|..|.|:  :.|:::..:|.:..|..:.::....:..|.:....::..:::..|.:|.|.:::
  Rat     2 LQEESDLSL--IIAQIVQKLKGSNLYAQLERQAWACLQRPEIRLESLKEDIKEFFKISGWEKKLQ 64

  Fly    66 NIVYNLVRTRLSKTDDKNLANKQGAKPT-VSDPLGYLKRAGVLWDRRVRKSLNAMCTELKVPLHG 129
            |.||       |:.:...|.:...|.|. :.:||.|:::|...|::|:.||||:|||||.:|| .
  Rat    65 NAVY-------SELNVFPLPSHPSAPPEHLKEPLVYMRKAQGSWEKRILKSLNSMCTELSIPL-A 121

  Fly   130 QPRISADREDFMAKWNELSNYNMDLANYRPVYAPKDLLEVLLSLKGPAKTTENTD---------- 184
            :.|...::::.:.||||:.....||:.:||||||||.||||::|:.|  ..||.|
  Rat   122 RKRPVGEQKELLNKWNEMGTDEPDLSLFRPVYAPKDFLEVLINLRNP--NYENGDSLSFRTHLGL 184

  Fly   185 -QIPQWEFSHIALPVKNLFELRAHYADLLRSDSYLGVPDLT-----------VQC-QRILEARHA 236
             |:|        |.||::.||:..:.:|..:...||:.|.|           |:. |::|..:.:
  Rat   185 IQVP--------LKVKDIPELKECFVELGLNTGQLGIDDSTQVPPELFENEHVRIGQKVLAQQDS 241

  Fly   237 PMCQQFLKKGCTPAPYRGALWASVLDSKLHDYDIEYWQKLRNAVWTTDHIVDKLVFKDIQLTASN 301
            ...||::::| :|...|..|||.:|:......||.|:::|:..|...|.:||.|::||::|||||
  Rat   242 AAAQQYVRQG-SPTALRAELWALILNISSQPEDILYYEQLKTNVIQHDLLVDSLIYKDVKLTASN 305

  Fly   302 DDQYFVFEDVLYQVLLCFSRDTDIGGCVEYETFP-----VKGKT--------YEGPPSGVVPFHG 353
            ||.||||||.||||||||||||.:.|...|.:..     ::||.        |  ||:||:||||
  Rat   306 DDYYFVFEDYLYQVLLCFSRDTSVLGHFAYNSASPPKSYIRGKLGLEEYAVFY--PPNGVIPFHG 368

  Fly   354 ICMFAAPFCYLYDSPVSLYYTFRAFYIRYCHRLTTINTHPQGIVSLCLLFEKLLQTYEPQLWSHF 418
            ..|:.||.|:||..|..||..||..|:|:..||.:|::||.||||||||||.|||||.|||:.|.
  Rat   369 FSMYVAPLCFLYHEPYKLYQIFREMYVRFFFRLHSISSHPSGIVSLCLLFETLLQTYLPQLFYHL 433

  Fly   419 RELQIQPLRVVFKWLMRAFSGHLPPDQLLVLWDLILGFDSLEILPLFAIIILSFRKESIMQVASL 483
            ||:..||||:.|||::|||||:|..||||:|||.|||::|||||.:.|..:.:||..::|:|.||
  Rat   434 REIGAQPLRISFKWMVRAFSGYLATDQLLLLWDRILGYNSLEILAVLAAAVFAFRAVNLMEVTSL 498

  Fly   484 DSIEAILADLSSIKVLPLVQLAL 506
            .:.||:|||||::||:||:|:.|
  Rat   499 AAAEAVLADLSTLKVMPLLQIFL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7742	NP_001285615.1	TBC	249..478	CDD:214540	125/241 (52%)
Tbc1d19	NP_001099478.1	TBC	248..466	CDD:214540	113/220 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354007
Domainoid	1	1.000	153	1.000	Domainoid score	I4208
eggNOG	1	0.900	-	-		E1_28K1A
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10130
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1946
OMA	1	1.010	-	-		QHG52833
OrthoDB	1	1.010	-	-		D1481068at2759
OrthoFinder	1	1.000	-	-		FOG0008286
OrthoInspector	1	1.000	-	-		oto98253
orthoMCL	1	0.900	-	-		OOG6_106228
Panther	1	1.100	-	-	LDO	PTHR16110
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770