Protein Alignment Cyp28d1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_608912.1
• Gene: Cyp28d1 / 33749
• FlyBaseID: FBgn0031689
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 140/608 - (23%)
• Similarity: 244/608 - (40%)
• Gaps: 154/608 - (25%)

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGS---FPSVFTQKRNVVYDIDEIYE 65
            ::.||.|  |:|||:..:.|..||..:|.|:...|..||:|:   |...|.:.:   .::.::|
Human    16 VTVALSV--ALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQ---MELRKLY- 74

  Fly    66 QYKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGE 130
                 ..:.|.:..|...::::.|:...::.|.:|.:| .|.||...:.|:   :|::...|..:
Human    75 -----GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNF-TNRMASGLEFKS---VADSVLFLRDK 130

  Fly   131 AWKERRAEVTPGLS------------ANRVK---------------------------------- 149
            .|:|.|..:....|            ..|:|
Human   131 RWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPF 195

  Fly   150 AAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDL--CLC-YTTEVISDCVLGISAQSFTDNPTPM 211
            ...|:..:.|...:.:::|.     |:..:|.|:  |.| |||:|::....|....|:.....|.
Human   196 CMVPLISQACDLLLAHLKRY-----AESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPF 255

  Fly   212 VGMTKRVFE-----------QSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQKCIQV 265
            |...||.||           .||..|. ..:|.:.|...:        .::..||..|::..|.:
Human   256 VKHCKRFFEFCIPRPILVLLLSFPSIM-VPLARILPNKNR--------DELNGFFNKLIRNVIAL 311

  Fly   266 RRESPAAQQRDDFLNYMLQLQEK-----------------------------------KGLNAAE 295
            |.:..|.::|.|||..:|..:..                                   :.|...|
Human   312 RDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDE 376

  Fly   296 LTSHTMTFLTDGFETTAQVLTHTLLF----LARNPKEQMKLREEIGTAE-----LTFEQISE-LP 350
            :......||..|:|    ::|:||.|    ||.||..|.||..|:...:     ..|..:.| ||
Human   377 IVGQAFIFLIAGYE----IITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLP 437

  Fly   351 FTEACIHETLRIFSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSF 415
            :.:..|.||||::.|.....:...:.||:..:     ::..|.|:.:.|.||||||:::..|::|
Human   438 YLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ-----RIPAGAVLEMAVGALHHDPEHWPSPETF 497

  Fly   416 KPERFLNINGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNE 480
            .||||   ...|::......:..||.|||.|.|:|..|.::|..|:.::..|..:..|:|:...:
Human   498 NPERF---TAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQ 559

  Fly   481 IDDTYFMPAL--KGGVWLDFVER 501
            ::.   ..||  |.||::..|.|
Human   560 LES---KSALGPKNGVYIKIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	CYP6-like	69..495	CDD:410679	118/532 (22%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	119/538 (22%)