Protein Alignment Cyp28d1 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_608912.1
• Gene: Cyp28d1 / 33749
• FlyBaseID: FBgn0031689
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 114/547 - (20%)
• Similarity: 219/547 - (40%)
• Gaps: 98/547 - (17%)

  Fly     3 PISTALFVIAAILA---LIYVFLTWNFSYWK--KRGIPTAKSWPFVGSFPSVFTQKRNVVYD--- 59
            |::|:.:::..::.   |:...|.|.::::.  :|          :..||.  ..|||..:.
Human    13 PVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRR----------LQCFPQ--PPKRNWFWGHLG 65

  Fly    60 -IDEIYEQYKNTDSIVGVFQTR--------IPQLMVTTPEYAHKI-YVSDFRSFHDNEMAKFTDS 114
             |....|..||:..:...:...        ||.:::..|:....| ..|...:..||...:|
Human    66 LITPTEEGLKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRF--- 127

  Fly   115 KTDPILANNPFVLTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLN 179
             ..|.|.....:..|:.|...|..:||....|.:|:    .:.:..|....:..:.....::|.:
Human   128 -LKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKS----YITIFNKSANIMLDKWQHLASEGSS 187

  Fly   180 AKDL---CLCYTTEVISDCVLGISAQSFTDNPTPMVG--------MTKRV--FEQSFGFIFYTVV 231
            ..|:   ....|.:.:..|:....:.. .:.|:..:.        :.||.  ..|...|::|
Human   188 RLDMFEHISLMTLDSLQKCIFSFDSHC-QERPSEYIATILELSALVEKRSQHILQHMDFLYY--- 248

  Fly   232 ANLWPPITKFYSVSLFAKDVAAFFYDLMQKCIQVRRESPAAQQRDDF---------LNYMLQL-- 285
              |.....:|:.       .....:|.....|:.||.:...|..|||         |:::..|
Human   249 --LSHDGRRFHR-------ACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLL 304

  Fly   286 ---QEKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEI-------GTAE 340
               ::.|.|:..::.:...||:..|.:|||..|:..|..|||:|:.|.:.|:|:       ...|
Human   305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKE 369

  Fly   341 LTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHD 405
            :.::.:::|||...|:.|:||:..|.....:..|:...|.:...:.    .|...:|.:..:||:
Human   370 IEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIP----KGITCLIDIIGVHHN 430

  Fly   406 PQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFD-I 469
            |..:.:|:.:.|.||...|   .|.|....|..|..|||.|.|..|::.::|..|..::.:|. :
Human   431 PTVWPDPEVYDPFRFDPEN---SKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL 492

  Fly   470 KVNPKTRKDNEIDDTYFMPALKGGVWL 496
            ..:.:.|:..|:    .|.| :||:||
Human   493 PDHTEPRRKLEL----IMRA-EGGLWL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	CYP6-like	69..495	CDD:410679	98/469 (21%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	101/474 (21%)