DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	506	Identity:	136/506 - (26%)
Similarity:	250/506 - (49%)	Gaps:	58/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDID-EIYEQYKNTDSI 73
            ::|..|.|:|::.|.:...:||.|||.....||:|   ::....|. :::.| |..|:|   ..:
Human    14 LVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLG---TILFYLRG-LWNFDRECNEKY---GEM 71

  Fly    74 VGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPI-----LANNPFVLTGEAWK 133
            .|:::.:.|.|::..|:....:.|.:..|...|:|         |:     |.:.......|.||
Human    72 WGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM---------PLGPMGFLKSALSFAEDEEWK 127

  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLG 198
            ..|..::|..::.:.|...|:..:.....|..:|:::  ..::.:|.||....||.:||:..:.|
Human   128 RIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEA--ENSKSINLKDFFGAYTMDVITGTLFG 190

  Fly   199 ISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQ 260
            ::..|..:...|.:...|::.:..|...|..:: :|:|   |:.:..::.||.|||..|..:.::
Human   191 VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI-SLFPFLTPVFEALNIGLFPKDVTHFLKNSIE 254

  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETTAQVLTHTL 319
            : ::..|.....:.|.||...|:..|..      |.|:..||.:.::..:...::||:..|...:
Human   255 R-MKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318

  Fly   320 LFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCEL 379
            ..||.:|..|.||:|||     ..|.:|::.:.::.:.:..::||||:|..|....:|..:..|:
Human   319 YELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383

  Fly   380 TNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPE-RFLNINGGAKKYRDQ---GLFFGFG 440
               |||.:.  .|..|::|:.||||||:|:.||:.|.|| ||      :||.:|.   ..:..||
Human   384 ---NGVFIP--KGLAVMVPIYALHHDPKYWTEPEKFCPESRF------SKKNKDSIDLYRYIPFG 437

  Fly   441 DGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALK 491
            .|||.|.||||:||.||.|::..::||..|...:|:...::|:   :|.|:
Human   438 AGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN---LPILQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	124/465 (27%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	127/481 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820