DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	532	Identity:	146/532 - (27%)
Similarity:	253/532 - (47%)	Gaps:	69/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68
            :|....::..::.|::::..|...::.|.|||..:.|||||:..|......|  :|:    |..|
Zfish     7 LSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRPWPFVGTLLSYAKGLCN--FDM----ECAK 65

  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPF-----VLT 128
            ....:.|::..|:|.|||...|....:.|.:..|...|...:.|.      || .||     ::.
Zfish    66 KYGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTG------LA-GPFSDGIIMVK 123

  Fly   129 GEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVIS 193
            .|.||..|:.::|..::.|:|..:|:::....:|::.::::.   |.|.:..|::...|:.:||:
Zfish   124 DERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKD---PEQPVKIKEVVAPYSLDVIT 185

  Fly   194 DCVLGISAQSFTDNPTPMVGMTKRVFE-QSFGFIFYTVVANLWP----PITKFYSVSLFAKDVAA 253
            .....:...|..:...|.|...|:..: ..|..:...::  |:|    |:.|. .|:||:|....
Zfish   186 SSSFSVDIDSINNPEDPFVINVKKFIQFNMFNPLLLLIL--LFPSLAIPLKKM-GVTLFSKSAMD 247

  Fly   254 FFYDLMQKCIQVRRESPAAQQRDDFLNYMLQ--------------LQEKKGLNAAELTSHTMTFL 304
            |||.:::|......:.  ::.|.|||..|||              .|..|||...|:.|.::.|:
Zfish   248 FFYSVLKKIKDDHNKE--SEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFI 310

  Fly   305 TDGFETTAQVLTHTLLFLARNPKEQMKLREEIG-----TAELTFEQISELPFTEACIHETLRIF- 363
            ..|:|||:..||..|..||.||....||.|||.     ...:|::.:..:.:.|..|:|::|:.
Zfish   311 LGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLLP 375

  Fly   364 -SPVL--AARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNING 425
             :|.|  :|:|.|.       .||:::.  .|.:|.||...|.|||..:|.|..|:||||...|
Zfish   376 TAPRLERSAKKTVV-------INGLTIP--EGTLVGIPTYVLSHDPDIWESPGEFRPERFSPEN- 430

  Fly   426 GAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPAL 490
              |....|..|..||.|||.|.|||:::..:|..:|::::||.::...:|:...|::.| |.|
Zfish   431 --KSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVT-FQP-- 490

  Fly   491 KGGVWLDFVERN 502
            |..:.|..:.|:
Zfish   491 KVPITLKLIPRS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	133/474 (28%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	134/479 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820