DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	504	Identity:	134/504 - (26%)
Similarity:	241/504 - (47%)	Gaps:	46/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68
            :|....::..:|.|:|::..|...::||.|||..:.|||.|:|.| :|:.   .::.|  .|..|
Zfish     7 LSVTWILVVLVLTLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLS-YTKG---FFNFD--MECAK 65

  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWK 133
            ....:.|::..|:|.||||..|....|.|.:..|...|......| ...| ||:....:..|.||
Zfish    66 KYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVD-LAGP-LADGITAVKDERWK 128

  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLG 198
            ..|..::|..::.|:|..:|:::....:|::.:::.....|   :..|::...|:.:|::.....
Zfish   129 RIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGDHEQP---VKIKEVMASYSLDVVTSSAFS 190

  Fly   199 ISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKF---YSVSLFAKDVAAFFYDLMQ 260
            :...|..:...|.|...|...:.:. |..:.::..::|.|...   ..:|:|:|....|||..::
Zfish   191 VDIDSINNPDDPFVTNIKNFLKFNL-FGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYKALR 254

  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQ-------------LQEKKGLNAAELTSHTMTFLTDGFETTA 312
            |   ::.|...:..|.||...|:|             .|.:|||...|:.|.:..|:..|:|||:
Zfish   255 K---IKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSEQPEKGLTDHEILSQSFIFIMGGYETTS 316

  Fly   313 QVLTHTLLFLARNPKEQMKLREEIG-----TAELTFEQISELPFTEACIHETLRIFSPVLAARKV 372
            ..||..|..||.||....||.|:|.     ...::::.:.::.:.|..|:|::|:........:|
Zfish   317 TTLTFLLYNLAINPDCLEKLVEKIDKNFPLDTPISYDALMKIDYLEMSINESMRLLPTAPRLERV 381

  Fly   373 VTEPCELTNKNGVSVKLRPGDVVI-IPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLF 436
            ..:..|:   ||:::   |.|.:| ||...|:.|||.::.|..|:||||...|   |....|..|
Zfish   382 CKKTVEM---NGITI---PKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPEN---KSEFLQYAF 437

  Fly   437 FGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTY 485
            ..||.|||.|.|||::|..:|..:|::::||.::...:|:...|::..:
Zfish   438 MPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLELNPVF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	124/463 (27%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	125/473 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910