DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	498	Identity:	139/498 - (27%)
Similarity:	243/498 - (48%)	Gaps:	50/498 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNV-VYDIDEIYEQYKNTDSI 73
            ::|.:.||:.::.:|...|:||.|||..|:.||.|   ::...|... |:|:| .:|:|   ..|
Zfish    10 LLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFG---TMLRYKDGFHVFDMD-CFEKY---GRI 67

  Fly    74 VGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERRAE 138
            .|::..|.|.|.:........:.:.:..|...|.    .:.:.:..|.:...:...:.|:..|:.
Zfish    68 WGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNR----RNFRLNGALYDAVSIAEDDDWRRIRSV 128

  Fly   139 VTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQS 203
            ::|..::.|:|..:.:..:.....|:.:.:.:  ...:..:.|:....|:.:|::.....:...|
Zfish   129 LSPSFTSGRLKEMFGIMKKHSHILVDSMGKTA--KRGESADIKEFFGAYSMDVVTSTAFSVDIDS 191

  Fly   204 FTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQKCIQV 265
            ..:...|.|...|::.:.......:.::| .:|   |:.:....:||...|..|||..:||....
Zfish   192 LNNPKDPFVTNIKKMLKFDLLNPLFLLIA-FFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSD 255

  Fly   266 RRESPAA----QQRDDFLNYMLQLQ-----------EKKGLNAAELTSHTMTFLTDGFETTAQVL 315
            |.....|    ::|.|||..|:..|           .:|||:..|:.|.:|.|:..|:||::..|
Zfish   256 RDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYETSSSTL 320

  Fly   316 THTLLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTE 375
            :.....||.||:...||:|||     ..|.:.:|.:..:.:.:|.:.|:||:| ||.|..:.|
Zfish   321 SFLFYNLATNPETMKKLQEEIDETFPNQAPVDYETLMSMDYLDAALSESLRLF-PVAARLERV-- 382

  Fly   376 PCELTNK-NGVSVKLRPGD-VVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFG 438
             |:.|.: ||:   |.|.| ||::|..|||.||.|:.||:|||||||..   |.|:..|..::..
Zfish   383 -CKKTVEINGL---LIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTK---GNKESIDPYMYMP 440

  Fly   439 FGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEI 481
            ||.|||.|.||||:...:|.|:|||::.||:.|..:|:...|:
Zfish   441 FGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLEL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	129/467 (28%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	130/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920