DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp3a41a

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_059092.2	Gene:	Cyp3a41a / 53973	MGIID:	1858451	Length:	504	Species:	Mus musculus

Alignment Length:	489	Identity:	142/489 - (29%)
Similarity:	239/489 - (48%)	Gaps:	51/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74
            ::|.||.|:|.:.|.....:||:|||..|..||:|:..:.:  |....:|: |.||:|..|   .
Mouse    14 LLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYY--KGLWKFDM-ECYEKYGKT---W 72

  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNE--------MAKFTDSKTDPILANNPFVLTGEA 131
            |:|..::|..::|.||....:.|.:..|...|.        |:|......|            |.
Mouse    73 GLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVGIMSKAISISKD------------EE 125

  Fly   132 WKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCV 196
            ||..||.::|..::.::|..:||..:.....|:|:.:::  ...:.:..||:...|:.:||:...
Mouse   126 WKRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLMQEA--EKGKPVTMKDVLGAYSIDVITSTS 188

  Fly   197 LGISAQSFTDNPTPMVGMTKRVFEQSF--GFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLM 259
            .|::..|..:...|.|...|.:....|  ..:|..|:.....|:.:..::.:|.||...||...:
Mouse   189 FGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFV 253

  Fly   260 QKCIQVRRESPAAQQRDDFLNYMLQLQEK-------KGLNAAELTSHTMTFLTDGFETTAQVLTH 317
            .:..:.|.:| ..:.|.|||..|:.....       |.|:..|:|:.::.|:..|:|||:..|:.
Mouse   254 NRMKESRLDS-KQKHRVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLSF 317

  Fly   318 TLLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPC 377
            ||..||.:|..|.||:|||     ..|..|::.:.|:.:.:..::||||::.......:...:..
Mouse   318 TLYCLATHPDIQKKLQEEIDETLPNKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDV 382

  Fly   378 ELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDG 442
            ||   |||.:.  .|..|:||..|||||||::.||:.|:||||...|.|:   .|..|:..||.|
Mouse   383 EL---NGVYIP--KGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGS---IDPYLYMPFGIG 439

  Fly   443 PRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476
            ||.|.||||:...:|.||.::::||..:...:|:
Mouse   440 PRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	132/464 (28%)
Cyp3a41a	NP_059092.2	p450	39..494	CDD:278495	132/464 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820