DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	144/489 - (29%)
Similarity:	240/489 - (49%)	Gaps:	51/489 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNV-VYDIDEIYEQYKNTDSI 73
            ::|.||.|.|.|.|.....:||:|||..|..||:|   :|....|.: .:|:    |.||....|
  Rat    14 LLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLG---TVLNYYRGLWKFDM----ECYKKCGKI 71

  Fly    74 VGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKT-DP--ILANNPFVLTGEAWKER 135
            .|:|..:.|...:...|....:.|.:..|.       ||:.:. .|  |::.:..|...|.||..
  Rat    72 WGLFDGQTPVFAIMDTEMIKSVLVKECFSV-------FTNRRNIGPVGIMSKSISVAKDEEWKRY 129

  Fly   136 RAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGIS 200
            ||.::|..::.|:|..:|:........|:|::::  :...:.|..|::...|:.:||:.....::
  Rat   130 RAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQK--VEKGKPLAMKEVFGAYSMDVITSTSFEVN 192

  Fly   201 AQSFTDNPTPMVGMTKRVFEQSFGF---IFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLM 259
            ..|..:...|.|...|:.  |.|.|   :|.:||  |:|   ||.:..::.||.||..|||...:
  Rat   193 INSINNPKDPFVEKVKKF--QRFDFFDPLFLSVV--LFPFLTPIYEMLNICLFPKDSVAFFQKFV 253

  Fly   260 QKCIQVRRESPAAQQRDDFLNYMLQLQEK-------KGLNAAELTSHTMTFLTDGFETTAQVLTH 317
            .:..|.|.:| ..:.|.|||..|:.....       |.|:..|:.:..:.|:...:|||:..|:.
  Rat   254 YRMKQTRLDS-KHKHRVDFLQLMMNAHNNSKDKVSHKALSDIEIVAQAIIFIFASYETTSSTLSF 317

  Fly   318 TLLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPC 377
            .|..||.:|..|.||:|||     ..|..|::.:.|:.:.:..::||.|::.......:|..:..
  Rat   318 VLYSLATHPDSQKKLQEEIDRALPNKAPPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDI 382

  Fly   378 ELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDG 442
            :|   :||.:.  .|.||:||...|.||||::.||:.|.||||...|.|:   .|..::..||:|
  Rat   383 KL---DGVFIP--KGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGS---IDPYVYLPFGNG 439

  Fly   443 PRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476
            ||.|.||||:|..:|.||.::::||..::..:|:
  Rat   440 PRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	133/464 (29%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	122/429 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010