DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	504	Identity:	138/504 - (27%)
Similarity:	241/504 - (47%)	Gaps:	46/504 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68
            :|....::..::.|:|::..|...::||.|||..:.|||.|:|.| :|:.   .::.|  .|..|
Zfish     7 LSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLS-YTKG---FFNFD--MECAK 65

  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWK 133
            ....:.|::..|:|.||||..|....|.|.:..|...|......| ...| ||:....:..|.||
Zfish    66 KYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVD-LAGP-LADGISAVKDERWK 128

  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLG 198
            ..|..::|..::.|:|..:|:::....:|::.::::....|   :..|::...|:.:|::.....
Zfish   129 RIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQP---VKIKEVVAPYSLDVVTSSSFS 190

  Fly   199 ISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKF---YSVSLFAKDVAAFFYDLMQ 260
            :...|..:...|.|...|...:.|. |....:...|:|.|...   ..:|:|::.:..|||..::
Zfish   191 VDIDSINNPDDPFVTNIKNFLKFSL-FSPLILFLTLFPSIANLLGKMGISVFSRSIMNFFYTALR 254

  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQ-------------LQEKKGLNAAELTSHTMTFLTDGFETTA 312
            |   ::.|...:..|.|||..|:|             .|..|||...|:.|.:..|:..|:|||:
Zfish   255 K---IKDEHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYETTS 316

  Fly   313 QVLTHTLLFLARNPKEQMKLREEIG-----TAELTFEQISELPFTEACIHETLRIFSPVLAARKV 372
            ..|:..|..||.||....||.|||.     ...::::.:.::.:.|..|:|::|:........:|
Zfish   317 TTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLPTAPRLERV 381

  Fly   373 VTEPCELTNKNGVSVKLRPGD-VVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLF 436
            ..:..||   ||:::   |.| :|.||...|:.|||.::.||.|:||||...|   |....|..|
Zfish   382 CKKTVEL---NGITI---PKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPEN---KSEFLQYAF 437

  Fly   437 FGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTY 485
            ..||.|||.|.||||:|..:|..:|::::||.::...:|:...|:...:
Zfish   438 MPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTPVF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	129/463 (28%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	130/473 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820