DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28d1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	136/540 - (25%)
Similarity:	251/540 - (46%)	Gaps:	70/540 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFP-SVFTQKRNVVYDIDEIYEQY 67
            |:.|||:|  :|.|:|.:....:..:.:||:...|.||.:|:.| ........|:..:.|::.
  Fly     6 IALALFII--LLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMIELHT-- 66

  Fly    68 KNTDS-IVGVFQTRIPQLMVTTPEYAHKIYVSDF------RSFHDNEMAKFTDSKTDPILANNPF 125
            |:|.| :.|::..|.....|..||....|.:.:|      .|.|:|..        :.||:.:..
  Fly    67 KHTGSPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQ--------ESILSKSLI 123

  Fly   126 VLTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQG--LNAKDLCLCYT 188
            .|....|||.|..:||..:.::::..|.:.....::.|.:|:.|..::....  |..||....:.
  Fly   124 SLRDGRWKEMRNILTPAFTGSKMRIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFA 188

  Fly   189 TEVISDCVLGISAQSF--TDNPTPMVGMT-KRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKD 250
            .:||:....|||..||  .||....:|.. .|:...|   :...::..|:|.:.|...:.:....
  Fly   189 NDVIATVAFGISINSFRRKDNEFFRIGQAMSRISAWS---VVKAMLYALFPRLMKVLRIQVLDTK 250

  Fly   251 VAAFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQLQEKK---------------GLNAAELTSHT 300
            ...:|..|:...::.|:|....  |.|.::.:::.::::               ...|.:|.:..
  Fly   251 NIDYFSSLVTAAMRYRQEHKVV--RPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQC 313

  Fly   301 MTFLTDGFETTAQVLTHTLLFLAR----NPKEQMKLREEIGTAE-------LTFEQISELPFTEA 354
            :.|...|||    :::.:|.||..    ||..|.:|.|||.:..       ||:::::::.:.:.
  Fly   314 LLFFFAGFE----IISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDM 374

  Fly   355 CIHETLRIFSPVLAARKVVTEPCELTNKNGVSV-KLRPGDVVIIPVNALHHDPQYYEEPQSFKPE 418
            .:.|.||.:.|.::..:...:..:|.::||..: ..|.|||:.||:.:|||||:.:|:|:.|.||
  Fly   375 VVLEALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPE 439

  Fly   419 RFLNINGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKD--NEI 481
            ||  .:|.|.:.|   ::..||.|||.|.|.|.:|.::|:.:.:::.||.:....:|.:|  |:|
  Fly   440 RF--ADGHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDI 499

  Fly   482 DDTYFMPALKGGVWLDFVER 501
            ......|  |.|.||.|..|
  Fly   500 RGHGLKP--KNGFWLKFEAR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	116/481 (24%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	122/499 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460890
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900