DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp6g2

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_610744.1	Gene:	Cyp6g2 / 36317	FlyBaseID:	FBgn0033696	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	143/529 - (27%)
Similarity:	236/529 - (44%)	Gaps:	58/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQ-YKNTD 71
            |.::|:::.:.::.|..::|||::.|:...:....||:...:...:.:....|.::|.. ....:
  Fly     6 LILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNHPDAENE 70

  Fly    72 SIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERR 136
            ..||:.....|.|::..||....|.|.||..|.:...:  :|.|.||:.:.|.|.|...||||.|
  Fly    71 PFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSS--SDPKGDPLGSQNIFFLKNPAWKEVR 133

  Fly   137 AEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQ---GLNAKDLCLCYTTEVISDCVLG 198
            .:::|..:.||:|..:|:...|......::|:|.|.....   .|.||:||..|||:||:....|
  Fly   134 LKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATVAYG 198

  Fly   199 ISAQSFTDNPTPMVGMTKRVFE------QSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYD 257
            :||.||||.........:.|||      ..|..:|:.      |.:..|....:...:...|...
  Fly   199 VSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFL------PHLVPFVRFKVVPAEATRFLRK 257

  Fly   258 LMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKGLNAAE------------LTSHTMTFLTDGFET 310
            .:...:..|.:|  .|:|:|.::.:::.:....|..|.            |.:..:.|.|.|||:
  Fly   258 TINYVMSEREKS--GQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFES 320

  Fly   311 TAQVLTHTLLFLARNPKEQMKLREEIGTA------ELTFEQISELPFTEACIHETLRIFSPVLAA 369
            ::..:...:..||::...|.:|||||..|      ::|.:.|..|.|.:..:.|.||::.|:...
  Fly   321 SSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPFL 385

  Fly   370 RKVVTEPCELTNKNGVSVKLRP---------GDVVIIPVNALHHDPQYYEEPQSFKPERFLNING 425
            .:..|        :|....|.|         |..|.||..|||.||||:.:|:.|.||||...|
  Fly   386 DRECT--------SGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPEN- 441

  Fly   426 GAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPAL 490
              :|......:..||.||..|.|.||...|.|..||.::||..|..:.:|....::|....:...
  Fly   442 --RKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQA 504

  Fly   491 KGGVWLDFV 499
            |||:.|..|
  Fly   505 KGGIHLRLV 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	130/478 (27%)
Cyp6g2	NP_610744.1	p450	36..511	CDD:278495	134/495 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460822
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900