DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28d1 and Cyp6g1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001286335.1	Gene:	Cyp6g1 / 36316	FlyBaseID:	FBgn0025454	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	242/533 - (45%)	Gaps:	61/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68
            ::..|||:.|.|..:|.:...|.|||:::|||.....|.:|:...||..:.:....:.|||...:
  Fly     3 LTEVLFVVVAALVALYTWFQRNHSYWQRKGIPYIPPTPIIGNTKVVFKMENSFGMHLSEIYNDPR 67

  Fly    69 NTD-SIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAW 132
            ..| ::||::....|.|::...|....|.:.||..|| |..|: .|...||:..||.|.:....|
  Fly    68 LKDEAVVGIYSMNKPGLIIRDIELIKSILIKDFNRFH-NRYAR-CDPHGDPLGYNNLFFVRDAHW 130

  Fly   133 KERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGL-NAKDLCLCYTTEVISDCV 196
            |..|.::||..::.:||..|.:...:.|.....::|:........: ..|::|..::|:.|:...
  Fly   131 KGIRTKLTPVFTSGKVKQMYTLMQEIGKDLELALQRRGEKNSGSFITEIKEICAQFSTDSIATIA 195

  Fly   197 LGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYT---------VVANLWPPITKFYSVSLFAKDVA 252
            .||.|.|. :||....        :::|...:|         .||...|.:.....:..|..|.:
  Fly   196 FGIRANSL-ENPNAEF--------RNYGRKMFTFTVARAKDFFVAFFLPKLVSLMRIQFFTADFS 251

  Fly   253 AFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKGLNAAE------------LTSHTMTFLT 305
            .|....:...::.|..|  ...|:|.::.::.|:::.   |||            |.:....|.|
  Fly   252 HFMRSTIGHVMEERERS--GLLRNDLIDVLVSLRKEA---AAEPSKPHYAKNQDFLVAQAGVFFT 311

  Fly   306 DGFETTAQVLTHTLLFLARNPKEQMKLREEI------GTAELTFEQISELPFTEACIHETLRIFS 364
            .||||::..::..|..:|::|:.|.:||:||      |...|::|:|..|.:....:.|.||::
  Fly   312 AGFETSSSTMSFALYEMAKHPEMQKRLRDEINEALVEGGGSLSYEKIQSLEYLAMVVDEVLRMY- 375

  Fly   365 PVL-----AARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNIN 424
            |||     ....|..:| :|:.|......|..|..|.||:.||||||:|:..|..|.||||...|
  Fly   376 PVLPFLDREYESVEGQP-DLSLKPFYDYTLENGTPVFIPIYALHHDPKYWTNPSQFDPERFSPAN 439

  Fly   425 GG---AKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYF 486
            ..   |..|:.      ||.||..|.|.|..|.|.|..||.:::|..::....|.||.:.|...|
  Fly   440 RKNIVAMAYQP------FGSGPHNCIGSRIGLLQSKLGLVSLLKNHSVRNCEATMKDMKFDPKGF 498

  Fly   487 MPALKGGVWLDFV 499
            :....||:.|:.|
  Fly   499 VLQADGGIHLEIV 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	128/478 (27%)
Cyp6g1	NP_001286335.1	p450	56..508	CDD:278495	129/475 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460821
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900