DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	498	Identity:	128/498 - (25%)
Similarity:	233/498 - (46%)	Gaps:	42/498 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQ--YKNT 70
            |.::.::..:.|::.....|:|::.|:...:.:|.||......|.|......|.:.:|.  ::|
  Fly     4 LLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFEN- 67

  Fly    71 DSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKER 135
            :..|||:.|..|.|::...|....:.:..|:.|::..:.  ||...|.:...|.|......|:|.
  Fly    68 EPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQ--TDPHNDALGYKNLFFARSPGWREL 130

  Fly   136 RAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGIS 200
            |.:::|..::.::|..||:.:::.|...:...|   :.....:..||||..:||::|:....|:.
  Fly   131 RTKISPVFTSGKIKQMYPLMVKIGKNLQDSAER---LGSGTEVQVKDLCSRFTTDLIATIAFGVE 192

  Fly   201 AQSFTDNPTPMVGMTKRVFEQS------FGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLM 259
            |.:..|..:......:.:|..:      |..||      :.|.:.....|.||:::...|....:
  Fly   193 ANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIF------MIPALASLARVKLFSRETTKFIRSSV 251

  Fly   260 QKCIQVRRESPAAQQRDDFLNYMLQLQEKKGLNAAE---------LTSHTMTFLTDGFETTAQVL 315
            ...::.|..:  .::|:|.::.:|.|:.:...|..:         |.:....|.|.||||:|..:
  Fly   252 NYVLKERERT--GEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSASTM 314

  Fly   316 THTLLFLARNPKEQMKLREEI----GTAE-LTFEQISELPFTEACIHETLRIFSPVLAARKVVTE 375
            |.||..||:|...|.:||:||    |..: :::|:|.|:|:....::||||.:..|....:..::
  Fly   315 TMTLYELAKNEALQDRLRQEIVDFFGDEDHISYERIQEMPYLSQVVNETLRKYPIVGYIERECSQ 379

  Fly   376 PCE---LTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFF 437
            |.|   .|.:...:::|..|..:.:...|:|.||||:.:|:.:.||||   |...:...:...:.
  Fly   380 PAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERF---NSSNRDNLNMDAYM 441

  Fly   438 GFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNE 480
            .||.|||.|.|||..|.|.|..||.|:||.......||.|..|
  Fly   442 PFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	121/466 (26%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	123/468 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460824
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900