DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	171/513 - (33%)
Similarity:	284/513 - (55%)	Gaps:	35/513 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 STALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKN 69
            |.||.::..::..||::|||:..||:|||:.||:....:|::|.:.|:|.|:|:|:.:||::||.
  Fly    37 SLALILLHLLVLPIYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYDKYKG 101

  Fly    70 TDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKF-TDSKTDPILANNPFVLTGEAWK 133
            ....||||.||.||::|..||.||::.||:||.:.|:..:.: ..:|.|.....|||..:|::|:
  Fly   102 KHRAVGVFVTRQPQILVLDPELAHEVLVSNFRCYKDSLQSSYLRHAKWDKYARLNPFWASGQSWR 166

  Fly   134 ERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQG-LNAKDLCLCYTTEVISDCVL 197
            ..|.:...|:|.:|::.||.:..:..:...||:.:|  :|.... |..:|||..||..|::|.:.
  Fly   167 RLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQ--VAEKNNILETRDLCFRYTAHVMADFIW 229

  Fly   198 GISAQSFTDNPTPMVGMTKRVFEQSFGFIFY-------TVVANLWPPITKFYSVSLFAKDVAAFF 255
            ||.|.:.| .|.......:.:..:...:.||       |:||.....:.:|   ..:.|:...||
  Fly   230 GIDAGTLT-RPMEQPNKVQEMASKWTSYAFYMLTLFMATIVAPCSRLLLRF---RFYPKETDEFF 290

  Fly   256 YDLMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLL 320
            .:|.::.|::|.:: ....|.|:|:::|||:::|.....:|..|.:|.:.||::|:...|.|.|.
  Fly   291 SNLTKESIELRLKA-GDSTRTDYLSHLLQLRDQKQATHDDLVGHALTVMLDGYDTSGTALLHALY 354

  Fly   321 FLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELT 380
            :||.||..|.|||.||     ....|.||::|.|.:.|..|:|:||:.|.:....||.|.|..:.
  Fly   355 YLAENPAVQQKLRVEILSCMASEKSLDFEKLSSLQYLEQVIYESLRLSSLIPQYTKVCTLPTVIR 419

  Fly   381 NKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRI 445
            .....|:.:..|..::||....|||.||:.||::||||||  .||..::...:|:|..|.|||||
  Fly   420 LSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERF--DNGAYQELMRKGIFLPFSDGPRI 482

  Fly   446 CPGMRFSLTQIKAALVEIVRNFDI-----KVNPKTRKDNEIDDTYFMPALKGGVWLDF 498
            |.|:..::..:|:|||.|:.||.:     ::.||       .|:.|...|:|.|.|::
  Fly   483 CMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPK-------GDSGFGVVLQGDVNLEY 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	152/460 (33%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	152/471 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472973
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG27358
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0007607
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.910