DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	128/522 - (24%)
Similarity:	231/522 - (44%)	Gaps:	47/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIY--EQYKNT 70
            |..|..||..::::....:.||::|.:...:....:|:...|...:.:....:...|  |:::|
  Fly     8 LLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN- 71

  Fly    71 DSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKER 135
            :.:||::....|.|::...:....:.|.||.|| .|..|| .|.::|.:.|.:.|:.....|:|.
  Fly    72 EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSF-SNRFAK-CDGRSDKMGALSLFLAKQPEWREI 134

  Fly   136 RAEVTPGLSANRVKAAYPVSLRV-C------KKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVIS 193
            |..:.|..:..::|..:.:...: |      |:....:||......|. ::.||:|..|.|::|:
  Fly   135 RTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAI-VSIKDVCDLYNTDMIA 198

  Fly   194 DCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDL 258
            ....|:.:.|..:..:.:....:.:|..:...|....|....|.:.......||.:..|.|...:
  Fly   199 SIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEFLRRV 263

  Fly   259 MQKCIQVRRESPAAQQRDDFLNYMLQLQEKKGL--NAAELTSH-------TMTFLTDGFETTAQV 314
            :|..|:.|..  ....|:|.:..:|.|:::..|  :.:..|.|       ..:|...|.||.:..
  Fly   264 IQLVIEERER--GGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCSAS 326

  Fly   315 LTHTLLFLARNPKEQMKLREEIGTA-------ELTFEQISELPFTEACIHETLRIFSPVLAARKV 372
            ::..|..||:.|..|.:||.||..|       .||:|.::.:.|.:..:.||||.: |::   .:
  Fly   327 MSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKY-PIV---PL 387

  Fly   373 VTEPCELTNKNGVSVKLRP--------GDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKK 429
            :...|...||... ..|||        |..|.|...|:||||:|:.:|..|.||||...|   |.
  Fly   388 LERECTPINKKRF-YSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAAN---KA 448

  Fly   430 YRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKGGV 494
            .:....:..||.|||.|.||:..|.|||..||..:....:::..:|.:..:.|..:.:.|.:..:
  Fly   449 LQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRI 513

  Fly   495 WL 496
            :|
  Fly   514 YL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	118/474 (25%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	119/471 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460823
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900